Sinclair-Smith C C, Emms M, Mills A E
Department of Pathology, Red Cross War Memorial Children's Hospital, Cape Town, South Africa.
Ultrastruct Pathol. 1989 Jul-Aug;13(4):443-9. doi: 10.3109/01913128909048494.
Three young children with characteristic fibroblastic tumors are presented. These comprised one case each of congenital fibrosarcoma, dermatofibrosarcoma protuberans, and fibrous hamartoma of infancy. Ultrastructural examination in each tumor revealed the presence of a peculiar intracisternal paracrystalline material that exhibited transverse periodicity between 18 and 22 nm. Elongated profiles lying within rough endoplasmic reticulum had a serpigenous outline. It is thought that this material is related to procollagen or its precursors and its presence may signify disorders of fibroblastic proliferation that may occur in fibrous tumors.
本文报告了3例具有特征性的成纤维细胞肿瘤患儿。其中包括1例先天性纤维肉瘤、1例隆突性皮肤纤维肉瘤和1例婴儿纤维性错构瘤。对每个肿瘤进行超微结构检查，均发现一种特殊的池内副晶状物质，其横向周期为18至22纳米。位于粗面内质网内的细长结构呈蜿蜒状轮廓。据认为，这种物质与前胶原或其前体有关，其存在可能表明纤维性肿瘤中可能发生的成纤维细胞增殖紊乱。
