Garcia Alexis, Lema Diego
Instituto de Inmunología, Facultad de Medicina, Universidad Central de Venezuela, Apartado 50109, Caracas 1050-A, Venezuela.
Curr Pharm Des. 2016;22(41):6294-6299. doi: 10.2174/1381612822666160915161302.
The need for the improvement of vaccine potency as well as reducing toxicity in healthy recipients has motivated studies of the formulation of vaccines regarding control of how, when, and where antigens and adjuvants encounter immune cells and other cells/tissues following vaccine administration. Immunostimulatory complexes (ISCOMs) and ISCOMATRIXTM adjuvants are versatile and flexible systems with various phospholipids and saponin components. They are being used in novel vaccines for either infectious diseases or cancer. This article presents a brief review of the latest developments using such adjuvants and possible new applications.
提高疫苗效力以及降低健康接种者的毒性的需求推动了疫苗制剂的研究，这些研究涉及控制疫苗接种后抗原和佐剂如何、何时以及在何处与免疫细胞及其他细胞/组织相遇。免疫刺激复合物（ISCOMs）和ISCOMATRIX™佐剂是具有多种磷脂和皂苷成分的通用且灵活的系统。它们正被用于针对传染病或癌症的新型疫苗中。本文简要综述了使用此类佐剂的最新进展以及可能的新应用。
