多杀性巴氏杆菌某些D型荚膜血清型菌株对兔多形核中性粒细胞吞噬作用的抗性。
Resistance of some capsular serotype D strains of Pasteurella multocida to rabbit polymorphonuclear neutrophil phagocytosis.
作者信息
Rush H G
机构信息
Unit for Laboratory Animal Medicine, University of Michigan Medical School, Ann Arbor 48109.
出版信息
Vet Microbiol. 1989 May;20(1):79-87. doi: 10.1016/0378-1135(89)90009-6.
The mechanism of resistance of Capsular Type D strains of Pasteurella multocida to killing by rabbit polymorphonuclear neutrophils (PMN) was studied using an in vitro assay that differentiates intra- from extracellular bacteria. Two Capsular Type D strains (3761 and 3766), resistant to killing by rabbit PMN, and one Type A strain (R1), susceptible to PMN destruction, were compared. After combining opsonized bacteria and PMN, the Capsular Type D Strains 3761 and 3766 remained extracellular while the Capsular Type A Strain R1 was internalized by PMN. Thus, both Type D strains were resistant to phagocytosis by rabbit PMN.
利用一种能区分细胞内和细胞外细菌的体外试验，研究了多杀性巴氏杆菌D型荚膜菌株对兔多形核中性粒细胞（PMN）杀伤的抗性机制。比较了两株对兔PMN杀伤具有抗性的D型荚膜菌株（3761和3766）和一株对PMN破坏敏感的A型菌株（R1）。将调理过的细菌与PMN混合后，D型荚膜菌株3761和3766仍存在于细胞外，而A型荚膜菌株R1被PMN内化。因此，两株D型菌株均对兔PMN的吞噬作用具有抗性。
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