吸烟与纹状体多巴胺D2/3受体：在吸烟与尼古丁依赖之间的联系中可能发挥的作用
Cigarette Use and Striatal Dopamine D2/3 Receptors: Possible Role in the Link between Smoking and Nicotine Dependence.
作者信息
Okita Kyoji, Mandelkern Mark A, London Edythe D
机构信息
Department of Psychiatry and Biobehavioral Sciences (Drs Okita and London), Department of Molecular and Medical Pharmacology (Dr London), and Brain Research Institute (Dr London), University of California, Los Angeles, CA.
Department of Research, VA Greater Los Angeles Healthcare System, Los Angeles, CA (Drs Okita, Mandelkern, and London); and.
出版信息
Int J Neuropsychopharmacol. 2016 Dec 3;19(11). doi: 10.1093/ijnp/pyw074. Print 2016 Nov.
BACKGROUND
Cigarette smoking induces dopamine release in the striatum, and smoking- or nicotine-induced ventral striatal dopamine release is correlated with nicotine dependence. Smokers also exhibit lower dopamine D2/3 receptor availability in the dorsal striatum than nonsmokers. Negative correlations of striatal dopamine D2/3 receptor availability with smoking exposure and nicotine dependence, therefore, might be expected but have not been tested.
METHODS
Twenty smokers had positron emission tomography scans with [F]fallypride to measure dopamine D2/3 receptor availability in ventral and dorsal regions of the striatum and provided self-report measures of recent and lifetime smoking and of nicotine dependence.
RESULTS
As reported before, lifetime smoking was correlated with nicotine dependence. New findings were that ventral striatal dopamine D2/3 receptor availability was negatively correlated with recent and lifetime smoking and also with nicotine dependence.
CONCLUSION
The results suggest an effect of smoking on ventral striatal D2/3 dopamine receptors that may contribute to nicotine dependence.
背景
吸烟会诱导纹状体中多巴胺的释放，且吸烟或尼古丁诱导的腹侧纹状体多巴胺释放与尼古丁依赖相关。吸烟者背侧纹状体中多巴胺D2/3受体的可用性也低于非吸烟者。因此，可能预期纹状体多巴胺D2/3受体可用性与吸烟暴露和尼古丁依赖呈负相关，但尚未得到验证。
方法
20名吸烟者接受了用[F]氟哌利多进行的正电子发射断层扫描，以测量纹状体腹侧和背侧区域的多巴胺D2/3受体可用性，并提供了近期和终生吸烟情况以及尼古丁依赖的自我报告测量数据。
结果
如之前所报道，终生吸烟与尼古丁依赖相关。新的发现是，腹侧纹状体多巴胺D2/3受体可用性与近期和终生吸烟以及尼古丁依赖均呈负相关。
结论
结果表明吸烟对腹侧纹状体D2/3多巴胺受体有影响，这可能导致尼古丁依赖。
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