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本文引用的文献

1
A mutation in the hepatitis E virus RNA polymerase promotes its replication and associates with ribavirin treatment failure in organ transplant recipients.戊型肝炎病毒 RNA 聚合酶的突变可促进其复制，并与器官移植受者的利巴韦林治疗失败相关。
Gastroenterology. 2014 Nov;147(5):1008-11.e7; quiz e15-6. doi: 10.1053/j.gastro.2014.08.040. Epub 2014 Aug 30.
2
Acute viral hepatitis - should the current screening strategy be modified?急性病毒性肝炎——当前的筛查策略是否需要修改？
J Clin Virol. 2014 Mar;59(3):184-7. doi: 10.1016/j.jcv.2014.01.001. Epub 2014 Jan 13.
3
Indigenous hepatitis E in England and wales from 2003 to 2012: evidence of an emerging novel phylotype of viruses.2003 年至 2012 年英格兰和威尔士的土著型戊型肝炎：新型病毒株出现的证据。
J Infect Dis. 2014 Apr 15;209(8):1212-8. doi: 10.1093/infdis/jit652. Epub 2013 Nov 23.
4
Hepatitis E virus in England and Wales: indigenous infection is associated with the consumption of processed pork products.英格兰和威尔士的戊型肝炎病毒：本土感染与食用加工猪肉制品有关。
Epidemiol Infect. 2014 Jul;142(7):1467-75. doi: 10.1017/S0950268813002318. Epub 2013 Sep 20.
5
Cross-species infections of cultured cells by hepatitis E virus and discovery of an infectious virus-host recombinant.经培养的细胞中戊型肝炎病毒的种间感染和传染性病毒-宿主重组的发现。
Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2438-43. doi: 10.1073/pnas.1018878108. Epub 2011 Jan 24.
6
Non-travel-associated hepatitis E in England and Wales: demographic, clinical, and molecular epidemiological characteristics.英格兰和威尔士非旅行相关戊型肝炎：人口统计学、临床及分子流行病学特征
J Infect Dis. 2005 Oct 1;192(7):1166-72. doi: 10.1086/444396. Epub 2005 Aug 22.
7
Evidence for the presence of hepatitis E virus in pigs in the United Kingdom.英国猪群中存在戊型肝炎病毒的证据。
Vet Rec. 2004 Feb 21;154(8):223-7. doi: 10.1136/vr.154.8.223.

来自英国一名患者血清的戊型肝炎病毒首个直接测序基因组。

First Directly Sequenced Genome of Hepatitis E Virus from the Serum of a Patient from the United Kingdom.

作者信息

Caddy Sarah L, Goodfellow Ian, Jalal Hamid

机构信息

Department of Pathology, Division of Virology, University of Cambridge, Cambridge, United Kingdom.

Public Health England, Cambridge, United Kingdom

出版信息

Genome Announc. 2016 Sep 15;4(5):e00931-16. doi: 10.1128/genomeA.00931-16.

DOI:10.1128/genomeA.00931-16
PMID:27634993
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5026433/
Abstract

Hepatitis E virus (HEV) genotype 3 is endemic in the United Kingdom but the complete sequence of HEV, generated directly from a clinical sample, is lacking. We report a near full-length genome sequence of genotype 3 HEV from the serum of a patient with acute hepatitis.

摘要

戊型肝炎病毒（HEV）3型在英国呈地方性流行，但缺乏直接从临床样本中获得的HEV完整序列。我们报告了1例急性肝炎患者血清中3型HEV的近全长基因组序列。