p21（WAF1）介导细胞周期抑制，与癌症抑制和治疗相关。
p21(WAF1) Mediates Cell-Cycle Inhibition, Relevant to Cancer Suppression and Therapy.
作者信息
El-Deiry Wafik S
机构信息
Department of Hematology/Oncology and Molecular Therapeutics Program, Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
出版信息
Cancer Res. 2016 Sep 15;76(18):5189-91. doi: 10.1158/0008-5472.CAN-16-2055.
Abstract
p21 (WAF1/CIP1; CDKN1a) is a universal cell-cycle inhibitor directly controlled by p53 and p53-independent pathways. Knowledge of the regulation and function of p21 in normal and cancer cells has opened up several areas of investigation and has led to novel therapeutic strategies. The discovery in 1993 and subsequent work on p21 has illuminated basic cellular growth control, stem cell phenotypes, the physiology of differentiation, as well as how cells respond to stress. There remain open questions in the signaling networks, the ultimate role of p21 in the p53-deficiency phenotype in the context of other p53 target defects, and therapeutic strategies continue to be a work in progress. Cancer Res; 76(18); 5189-91. ©2016 AACRSee related article by El-Deiry et al., Cancer Res 1994;54:1169-74Visit the Cancer Research 75(th) Anniversary timeline.
摘要
p21（WAF1/CIP1；CDKN1a）是一种普遍的细胞周期抑制剂，直接受p53和非p53依赖途径的调控。对p21在正常细胞和癌细胞中的调控及功能的了解，开启了多个研究领域，并催生了新的治疗策略。1993年对p21的发现及后续研究阐明了基本的细胞生长控制、干细胞表型、分化生理学，以及细胞如何应对应激。在信号网络、p21在其他p53靶点缺陷背景下的p53缺陷表型中的最终作用等方面仍存在未解决的问题，治疗策略也仍在不断完善中。《癌症研究》；76(18)；5189 - 91。©2016美国癌症研究协会。见El-Deiry等人的相关文章，《癌症研究》1994；54:1169 - 74。访问《癌症研究》75周年时间轴。
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