Kuliev N A
Vestn Dermatol Venerol. 1989(4):54-9.
The findings of biochemical studies, carried out in 30 patients suffering from psoriatic arthropathy, are analyzed. The parameters examined are: the blood and urine glycosaminoglycans, urine hydroxyproline levels, and blood hyaluronate glycan hydrolase and N-acetyl-B-D-glucosaminidase activities, i. e. the matrix and collagen metabolites as the indicators of the connective tissue destruction and lysosomal enzymes activation responsible, among other factors, for this destruction. The studies have revealed a correlation between the enzymic activity augmentation and the levels of the connective tissue degradation products and the dissemination and severity of the skin and articular processes. The patients have been treated with mefenamic acid, an enzymic activity inhibitor. The therapy has been effective in 76% of patients; 13% of these have developed a remission shortly after therapy (in 46.7 days on an average). The therapy has alleviated both skin and articular symptoms; a tendency to normalization of the biochemical characteristics has been observed. A continuous course of therapy has not been associated with side effects. The author recommends this pathogenetically based and confirmed by laboratory investigations method to be included into a complex of therapeutic measures for patients with psoriatic arthropathy.
对30例银屑病关节炎患者进行的生化研究结果进行了分析。所检测的参数包括：血液和尿液中的糖胺聚糖、尿液羟脯氨酸水平以及血液中的透明质酸聚糖水解酶和N-乙酰-β-D-葡萄糖胺酶活性，即作为结缔组织破坏指标的基质和胶原蛋白代谢产物，以及负责这种破坏的溶酶体酶激活。研究揭示了酶活性增强与结缔组织降解产物水平以及皮肤和关节病变的扩散和严重程度之间的相关性。患者接受了甲芬那酸治疗，一种酶活性抑制剂。该疗法在76%的患者中有效；其中13%在治疗后不久出现缓解（平均46.7天）。该疗法缓解了皮肤和关节症状；观察到生化特征有正常化的趋势。持续的治疗过程未出现副作用。作者建议将这种基于发病机制并经实验室研究证实的方法纳入银屑病关节炎患者的综合治疗措施中。
