Jefferis A F, Berenbaum M C
Ear, Nose and Throat Department, St. Mary's Hospital Medical School, London, England.
Acta Otolaryngol. 1989 Jul-Aug;108(1-2):152-60. doi: 10.3109/00016488909107407.
Animal models of carcinomas can provide useful information for the evaluation of new treatments. In the rabbit, the VX2 tumour is a fast growing, transplantable squamous cell carcinoma. By implanting a cell suspension of the tumour into the tongue and/or the larynx, a useful new model for studying or treating tumours in this region has been developed. The tumours were evaluated histologically and showed features consistent with human carcinomas, including surface ulceration, lymphatic spread and encroachment of the airway. The VX2 tumours in these sites have features which offer advantages over existing models. These include the ability to study several sites of tumour growth in the same animal, to follow rapidly growing tumours, storage of the tumour in liquid nitrogen allowing experiments to be started when convenient, and the large size of the rabbit larynx which permits considerable tumour growth before airway embarrassment.
癌症动物模型可为评估新疗法提供有用信息。在兔子身上，VX2肿瘤是一种生长迅速、可移植的鳞状细胞癌。通过将肿瘤细胞悬液植入舌头和/或喉部，已开发出一种用于研究或治疗该区域肿瘤的有用新模型。对肿瘤进行组织学评估，结果显示其特征与人类癌症一致，包括表面溃疡、淋巴转移和气道侵犯。这些部位的VX2肿瘤具有一些优于现有模型的特征。其中包括能够在同一只动物身上研究肿瘤生长的多个部位、跟踪快速生长的肿瘤、将肿瘤保存在液氮中以便在方便时开展实验，以及兔子喉部较大，在气道受影响之前允许肿瘤大量生长。
