Matos Tiago R, Sheth Vaneeta
Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Academic Medical Center, Department of Dermatology, University of Amsterdam, Amsterdam, 1105 AZ, Netherlands.
Newton-Wellesley Hospital, Newton, MA.
Clin Dermatol. 2016 Sep-Oct;34(5):538-47. doi: 10.1016/j.clindermatol.2016.05.003. Epub 2016 May 20.
The health benefits of natural sunlight have been noted since the rise of civilization, even without the knowledge of its mechanisms of action. Currently, phototherapy remains an effective and widely used treatment for a variety of skin diseases. Ultraviolet radiation, from either the sun or artificial light sources, has a profound immunomodulatory effect that is responsible for its beneficial clinical outcomes. Ultraviolet radiation mostly induces the innate while suppressing the adaptive immune system, leading to both local and systemic effects. It is antigen specific, acts on both effector and regulatory T cells, alters antigen-presenting cell function, and induces the secretion of cytokines and soluble mediators. This review provides an overview of the immunologic mechanisms by which ultraviolet radiation is responsible for the therapeutic effects of phototherapy.
自文明兴起以来，自然光对健康的益处就已被人们所注意，即便当时尚不了解其作用机制。目前，光疗仍是治疗多种皮肤病的一种有效且广泛应用的疗法。来自太阳或人造光源的紫外线具有深刻的免疫调节作用，这正是其产生有益临床效果的原因。紫外线主要诱导先天免疫系统，同时抑制适应性免疫系统，从而产生局部和全身效应。它具有抗原特异性，作用于效应T细胞和调节性T细胞，改变抗原呈递细胞的功能，并诱导细胞因子和可溶性介质的分泌。本综述概述了紫外线产生光疗治疗效果的免疫机制。
