Martin Baptiste, Hoenen Thomas, Canard Bruno, Decroly Etienne
Laboratoire Architecture et Fonction des Macromolécules Biologiques (AFMB), UMR7257 CNRS, Parc Scientifique de Luminy, Aix-Marseille Université, Marseille, France.
Friedrich-Loeffler-Institut, Greifswald, Insel Riems, Germany.
Antiviral Res. 2016 Nov;135:1-14. doi: 10.1016/j.antiviral.2016.09.001. Epub 2016 Sep 14.
This review focuses on the recent progress in our understanding of filovirus protein structure/function and its impact on antiviral research. Here we focus on the surface glycoprotein GP and its different roles in filovirus entry. We first describe the latest advances on the characterization of GP gene-overlapping proteins sGP, ssGP and Δ-peptide. Then, we compare filovirus surface GP proteins in terms of structure, synthesis and function. As they bear potential in drug-design, the discovery of small organic compounds inhibiting filovirus entry is a currently very active field. Although it is at an early stage, the development of antiviral drugs against Ebola and Marburg virus entry might prove essential to reduce outbreak-associated fatality rates through post-exposure treatment of both suspected and confirmed cases.
本综述聚焦于我们对丝状病毒蛋白结构/功能的理解以及其对抗病毒研究的影响方面的最新进展。在此，我们着重探讨表面糖蛋白GP及其在丝状病毒进入过程中的不同作用。我们首先描述GP基因重叠蛋白sGP、ssGP和Δ-肽的表征方面的最新进展。然后，我们从结构、合成和功能方面比较丝状病毒表面GP蛋白。由于它们在药物设计方面具有潜力，发现抑制丝状病毒进入的有机小分子化合物是当前一个非常活跃的领域。尽管尚处于早期阶段，但开发针对埃博拉病毒和马尔堡病毒进入的抗病毒药物对于通过对疑似和确诊病例进行暴露后治疗来降低疫情相关死亡率可能至关重要。
