Institute for Integrative Biology of the Cell (I2BC), Centre National de la Recherche Scientifique (CNRS), The French Alternative Energies and Atomic Energy Commission (CEA), University Paris-Saclay, 1 Avenue de la Terrasse, F-91198 Gif-sur-Yvette, France.
Nat Rev Microbiol. 2016 Dec;14(12):775-784. doi: 10.1038/nrmicro.2016.129. Epub 2016 Sep 19.
Many bacterial regulatory small RNAs (sRNAs) have several mRNA targets, which places them at the centre of regulatory networks that help bacteria to adapt to environmental changes. However, different mRNA targets of any given sRNA compete with each other for binding to the sRNA; thus, depending on relative abundances and sRNA affinity, competition for regulatory sRNAs can mediate cross-regulation between bacterial mRNAs. This 'target-centric' perspective of sRNA regulation is reminiscent of the competing endogenous RNA (ceRNA) hypothesis, which posits that competition for a limited pool of microRNAs (miRNAs) in higher eukaryotes mediates cross-regulation of mRNAs. In this Opinion article, we discuss evidence that a similar network of RNA crosstalk operates in bacteria, and that this network also includes crosstalk between sRNAs and competition for RNA-binding proteins.
许多细菌调节性小 RNA（sRNA）有几个 mRNA 靶标，这使它们处于帮助细菌适应环境变化的调节网络的中心。然而，给定 sRNA 的不同 mRNA 靶标相互竞争与 sRNA 的结合；因此，取决于相对丰度和 sRNA 的亲和力，调节 sRNA 的竞争可以介导细菌 mRNA 之间的交叉调节。这种以“靶标为中心”的 sRNA 调节观点让人联想到竞争内源性 RNA（ceRNA）假说，该假说认为，在高等真核生物中，有限的 miRNA （miRNA）库的竞争介导了 mRNA 的交叉调节。在本观点文章中，我们讨论了证据表明，类似的 RNA 串扰网络在细菌中起作用，并且该网络还包括 sRNA 之间的串扰和 RNA 结合蛋白的竞争。
