Ansari Mansour, Porouhan Pezhman, Mohammadianpanah Mohammad, Omidvari Shapour, Mosalaei Ahmad, Ahmadloo Niloofar, Nasrollahi Hamid, Hamedi Seyed Hasan
Radiation Oncology, Shiraz University of Medical Sciences, Shiraz, Iran E-mail :
Asian Pac J Cancer Prev. 2016;17(8):3877-80.
Nausea and vomiting are among the most serious side effects of chemotherapy, in some cases leading to treatment interruption or chemotherapy dose reduction. Ginger has long been known as an antiemetic drug, used for conditions such as motion sickness, nausea-vomiting in pregnancy, and post-operation side effects. One hundred and fifty female patients with breast cancer entered this prospective study and were randomized to receive ginger (500 mg ginger powder, twice a day for 3 days) or placebo. One hundred and nineteen patients completed the study: 57 of them received ginger and 62 received ginger for the frst 3 chemotherapy cycles. Mean age in all patients was 48.6 (25-79) years. After 1st chemotherapy, mean nausea in the ginger and control arms were 1.36 (±1.31) and 1.46 (±1.28) with no statistically significant difference. After the 2nd chemotherapy session, nausea score was slightly more in the ginger group (1.36 versus 1.32). After 3rd chemotherapy, mean nausea severity in control group was less than ginger group [1.37 (±1.14), versus 1.42 (±1.30)]. Considering all patients, nausea was slightly more severe in ginger arm. In ginger arm mean nausea score was 1.42 (±0.96) and in control arm it was 1.40 (±0.92). Mean vomiting scores after chemotherapy in ginger arm were 0.719 (±1.03), 0.68 (±1.00) and 0.77 (±1.18). In control arm, mean vomiting was 0.983 (±1.23), 1.03 (±1.22) and 1.15 (±1.27). In all sessions, ginger decreased vomiting severity from 1.4 (±1.04) to 0.71 (±0.86). None of the differences were significant. In those patients who received the AC regimen, vomiting was less severe (0.64±0.87) compared to those who received placebo (1.13±1.12), which was statistically significant (p-value <0.05). Further and larger studies are needed to draw conclusions.
恶心和呕吐是化疗最严重的副作用之一，在某些情况下会导致治疗中断或化疗剂量减少。长期以来，生姜一直被视为一种止吐药物，用于治疗晕动病、妊娠恶心呕吐以及术后副作用等病症。150名患有乳腺癌的女性患者参与了这项前瞻性研究，并被随机分为两组，分别接受生姜治疗（500毫克姜粉，每天两次，共3天）或安慰剂治疗。119名患者完成了研究：其中57人接受了生姜治疗，62人在最初的3个化疗周期接受了生姜治疗。所有患者的平均年龄为48.6岁（25 - 79岁）。第一次化疗后，生姜组和对照组的平均恶心评分为1.36（±1.31）和1.46（±1.28），无统计学显著差异。第二次化疗后，生姜组的恶心评分略高于对照组（1.36对1.32）。第三次化疗后，对照组的平均恶心严重程度低于生姜组[1.37（±1.14）对1.42（±1.30）]。综合所有患者来看，生姜组的恶心症状略更严重。生姜组的平均恶心评分为1.42（±0.96），对照组为1.40（±0.92）。生姜组化疗后的平均呕吐评分为0.719（±1.03）、0.68（±1.00）和0.77（±1.18）。对照组的平均呕吐评分为0.983（±1.23）、1.03（±1.22）和1.15（±1.27）。在所有疗程中，生姜将呕吐严重程度从1.4（±1.04）降至0.71（±0.86）。所有差异均无统计学显著性。在接受AC化疗方案的患者中，呕吐症状比接受安慰剂的患者更轻（0.64±0.87对1.13±1.12），具有统计学显著性（p值<0.05）。需要进一步开展更大规模的研究才能得出结论。
