Sanaati Fateme, Najafi Safa, Kashaninia Zahra, Sadeghi Masoud
Department of Nursing, University of Welfare and Rehabilitation Sciences, Tehran, Iran E-mail :
Asian Pac J Cancer Prev. 2016;17(8):4125-9.
Chemotherapy-induced nausea and vomiting (CINV) places a significant burden on the patient. Herbal agents are the most commonly complementary therapies used among the public. This study was done to determine the effect of ginger and chamomile capsules on nausea and vomiting in cases undergoing chemotherapy for breast cancer (BC).
In a randomized, double-blind and clinical trial study, 65 women with BC undergoing chemotherapy were referred to Breast Cancer Research Center, Tehran, Iran, between May 2013 to June 2014. Regimen for ginger group for 5 days before and 5 days after chemotherapy was: 2 times a day and 500 mg capsules of powdered ginger root in addition to a routine antiemetic regimen consisting of dexamethasone, metoclopramide and aprepitant (DMA) capsules. Chamomile group similarly was: 2 times a day and 500 mg capsules of Matricaria chamomilla extract in addition to a routine antiemetic regimen consisting of DMA capsules. Control group, routine antiemetic regimen consisting of DMA capsules.
There were no significant differences between the ginger, chamomile and control groups regarding age. Drugs used for chemotherapy were identical and duration of disease was also matched (1-4 months). Ginger and chamomile were both significantly effective for reducing the frequency of vomiting, there being no significant difference between the ginger and chamomile groups. Moreover, unlike the chamomile, ginger significantly influenced the frequency of nausea.
According to the findings of this study, it should be declared that taking ginger capsules (1 g/day) might relieve CINV safely. Nurses dealing directly with cancer patients should be responsible for providing educational programs for patients and their families about how to deal with their drug regimens and associated side effects.
化疗引起的恶心和呕吐（CINV）给患者带来了沉重负担。草药制剂是公众最常用的辅助疗法。本研究旨在确定姜胶囊和洋甘菊胶囊对乳腺癌（BC）化疗患者恶心和呕吐的影响。
在一项随机、双盲临床试验研究中，2013年5月至2014年6月期间，65名接受化疗的BC女性患者被转诊至伊朗德黑兰乳腺癌研究中心。姜组在化疗前5天和化疗后5天的用药方案为：除了由地塞米松、甲氧氯普胺和阿瑞匹坦（DMA）胶囊组成的常规止吐方案外，每天2次，服用500毫克姜根粉胶囊。洋甘菊组同样为：除了由DMA胶囊组成的常规止吐方案外，每天2次，服用500毫克洋甘菊提取物胶囊。对照组采用由DMA胶囊组成的常规止吐方案。
姜组、洋甘菊组和对照组在年龄方面无显著差异。化疗所用药物相同，病程也匹配（1 - 4个月）。姜和洋甘菊在减少呕吐频率方面均有显著效果，姜组和洋甘菊组之间无显著差异。此外，与洋甘菊不同的是，姜对恶心频率有显著影响。
根据本研究结果，应声明服用姜胶囊（1克/天）可能安全缓解CINV。直接护理癌症患者的护士应负责为患者及其家属提供有关如何应对其药物治疗方案及相关副作用的教育项目。
