在接受前列腺活检的患者的前列腺组织中存在 HPV。
Presence of HPV in prostate tissue from patients submitted to prostate biopsy.
机构信息
MSc, associate professor. Universidade Federal do Amapá - Department of Medicine - Macapá (AP), Brazil.
PhD, associate professor. Universidade Federal do Amapá - Department of Medicine - Macapá (AP), Brazil.
出版信息
Acta Cir Bras. 2023 Jan 13;37(12):e371205. doi: 10.1590/acb371205. eCollection 2023.
PURPOSE
Prostate cancer (PCa) is the second most frequent cancer among men in the Western population. Infections, such as the one caused by the human papillomavirus (HPV), have been shown to promote inflammation that can lead to the appearance of neoplasms. This study aimed to verify the presence of HPV in neoplastic and non-neoplastic prostate tissue in patients undergoing prostate biopsy and its possible relationship with PCa.
METHODS
Prostate tissue fragments were collected by prostate biopsy and subjected to polymerase chain reaction with primers for the HPV L1 gene to identify the presence of the virus.
RESULTS
Among 162 patients, 10 (6.2%) had HPV and in 152 (93.8%) HPV was not identified in prostate biopsies. HPV was detected in 7/95 (7.4%) of patients with PCa, in 2/55 (3.6%) of patients without PCa, and in no patient with an inconclusive diagnosis of PCa. There was no significant difference (p = 0.487) of HPV presence in the tissue of patients with PCa.
CONCLUSIONS
There were no significant levels of HPV L1 protein in prostate tissue. The findings suggest the absence of HPV oncogenic activity in the prostate tissue of patients with PCa.
目的
前列腺癌（PCa）是西方男性中第二常见的癌症。已经发现，感染（如人乳头瘤病毒（HPV）感染）会引起炎症，从而导致肿瘤的出现。本研究旨在验证接受前列腺活检的患者的肿瘤和非肿瘤前列腺组织中 HPV 的存在及其与 PCa 的可能关系。
方法
通过前列腺活检收集前列腺组织碎片，并使用针对 HPV L1 基因的引物进行聚合酶链反应，以确定病毒的存在。
结果
在 162 名患者中，有 10 名（6.2%）存在 HPV，而在 152 名（93.8%）患者的前列腺活检中未发现 HPV。在 95 名 PCa 患者中有 7 名（7.4%）检测到 HPV，在 55 名无 PCa 患者中有 2 名（3.6%）检测到 HPV，在无 PCa 诊断不确定的患者中未检测到 HPV。PCa 患者组织中 HPV 存在的差异无统计学意义（p = 0.487）。
结论
前列腺组织中 HPV L1 蛋白水平没有显著差异。研究结果表明，在 PCa 患者的前列腺组织中不存在 HPV 致癌活性。
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