2004年至2014年中国肠球菌分离株中新型恶唑烷酮耐药基因optrA的全国性监测
Nationwide Surveillance of Novel Oxazolidinone Resistance Gene optrA in Enterococcus Isolates in China from 2004 to 2014.
作者信息
Cui Lanqing, Wang Yang, Lv Yuan, Wang Shan, Song Yunjia, Li Yun, Liu Jian, Xue Feng, Yang Weiwei, Zhang Jia
机构信息
Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China.
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China.
出版信息
Antimicrob Agents Chemother. 2016 Nov 21;60(12):7490-7493. doi: 10.1128/AAC.01256-16. Print 2016 Dec.
Abstract
A total of 2,201 nonduplicate enterococcal isolates collected from 29 hospitals in 23 cities in China between 2004 and 2014 were screened for the oxazolidinone resistance gene optrA; 45 isolates (2.0%) were optrA positive with 11 OptrA variants identified. The positive rate of optrA increased from 0.4% to 3.9% during the 10-year surveillance period. Pulsed-field gel electrophoresis (PFGE) and multilocus sequence type (MLST) analysis revealed that 37 optrA-positive Enterococcus faecalis isolates clustered into 25 PFGE patterns and 21 sequence types, while 6 Enterococcus faecium isolates represented 6 PFGE patterns and 6 sequence types. The present study underscores the importance of routine and persistent monitoring of oxazolidinone resistance and optrA gene.
摘要
2004年至2014年间，从中国23个城市的29家医院收集了2201株非重复肠球菌分离株，对其进行恶唑烷酮耐药基因optrA筛查；45株（2.0%）optrA呈阳性，鉴定出11种OptrA变体。在10年监测期内，optrA阳性率从0.4%升至3.9%。脉冲场凝胶电泳（PFGE）和多位点序列分型（MLST）分析显示，37株optrA阳性粪肠球菌分离株聚为25种PFGE型和21种序列型，而6株屎肠球菌分离株代表6种PFGE型和6种序列型。本研究强调了对恶唑烷酮耐药性和optrA基因进行常规和持续监测的重要性。
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