Clinical Microbiology Laboratory, The Second Affiliated Hospital of Zhejiang University, Zhejiang University, Hangzhou, China.
Department of Veterinary Pharmacology, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Clin Microbiol Infect. 2015 Dec;21(12):1095.e1-4. doi: 10.1016/j.cmi.2015.08.007. Epub 2015 Aug 28.
A collection of 1159 enterococcal isolates from five Chinese hospitals were screened for the presence of the novel oxazolidinone resistance gene optrA, which was found in 34 (2.9%) isolates. Pulsed-field gel electrophoresis (PFGE) typing of 29 optrA-carrying Enterococcus faecalis isolates revealed 25 PFGE patterns, and multilocus sequence typing yielded 20 sequence types. Routine surveillance of optrA-positive enterococci in hospitals should be conducted to monitor and counteract their further dissemination. The data of this study may be used as a baseline from which to judge future decreases or increases in optrA-positive enterococci.
从中国的五家医院收集了 1159 株肠球菌分离株，对新型恶唑烷酮类药物耐药基因 optrA 的存在情况进行了筛选，结果在 34 株（2.9%）分离株中发现了该基因。对 29 株携带 optrA 的粪肠球菌分离株进行脉冲场凝胶电泳（PFGE）分型，显示 25 种 PFGE 模式，多位点序列分型得到 20 种序列型。应在医院中对 optrA 阳性肠球菌进行常规监测，以监测和阻止其进一步传播。本研究的数据可作为判断未来 optrA 阳性肠球菌减少或增加的基线。
