在一种草本补充剂中鉴定出一种新的西地那非类似物掺杂物——去乙基卡波地那非。
Identification of a new sildenafil analogue adulterant, desethylcarbodenafil, in a herbal supplement.
作者信息
Huang Yen-Chun, Lee Hui-Chun, Lin Yun-Lian, Lin Ya-Tze, Tsai Chia-Fen, Cheng Hwei-Fang
机构信息
a Chemical Lab , Super Laboratory Company Ltd , New Taipei , Taiwan (R.O.C.).
b Division of Research and Analysis , Taiwan Food and Drug Administration , Taipei , Taiwan (R.O.C.).
出版信息
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2016 Nov;33(11):1637-1642. doi: 10.1080/19440049.2016.1236402. Epub 2016 Oct 11.
In a maca-containing herbal supplement claimed to remedy erectile dysfunction, a new sildenafil analogue was found using adulterant screening with TLC, GC-MS and LC-MS/MS. This compound was isolated by column chromatography and HPLC, and identified by extensive 1D- and 2D-NMR and mass spectral analyses. The structure of this new compound was established as 5-[2-ethoxy-5-(piperazine-1-carbonyl) phenyl]-1-methyl-3-propyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one, and was named desethylcarbodenafil.
在一种声称可治疗勃起功能障碍的含玛咖草本补充剂中，通过薄层色谱法（TLC）、气相色谱 - 质谱联用（GC-MS）和液相色谱 - 串联质谱联用（LC-MS/MS）进行掺假筛查时发现了一种新的西地那非类似物。该化合物通过柱色谱法和高效液相色谱法（HPLC）分离，并通过广泛的一维和二维核磁共振（1D-和2D-NMR）以及质谱分析进行鉴定。这种新化合物的结构确定为5-[2-乙氧基-5-(哌嗪-1-羰基)苯基]-1-甲基-3-丙基-1,6-二氢-吡唑并[4,3-d]嘧啶-7-酮，并被命名为去乙基卡波地那非。
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