草药产品中一种新型西地那非类似物掺假物的分离与鉴定。
Isolation and identification of a novel sildenafil analogue adulterant in herbal products.
作者信息
Lin Ya-Tze, Huang Yen-Chun, Lee Hui-Chun, Liao Chen-Hsiang, Lin Yun-Lian, Tsai Chia-Fen, Cheng Hwei-Fang
机构信息
a Division of Research and Analysis , Taiwan Food and Drug Administration , Taipei City , Taiwan (ROC).
b Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources , China Medical University , Taichung , Taiwan (ROC).
出版信息
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2017 Mar;34(3):330-334. doi: 10.1080/19440049.2016.1272137. Epub 2016 Dec 23.
A novel sildenafil analogue found in herbal products by a routine drug-adulteration screening programme was isolated by column chromatography. On the basis of extensive 1D- and 2D-nuclear magnetic resonance (NMR) spectroscopy and mass spectral analysis, the structure of a new compound YJ-07 was established as 1-[4-ethoxy-3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl) benzenesulfonamide. It common name is aminosildenafil.
通过常规药物掺假筛查程序在草药产品中发现的一种新型西地那非类似物，采用柱色谱法进行分离。基于广泛的一维和二维核磁共振（NMR）光谱以及质谱分析，确定了新化合物YJ - 07的结构为1 - [4 - 乙氧基 - 3 -（6,7 - 二氢 - 1 - 甲基 - 7 - 氧代 - 3 - 丙基 - 1H - 吡唑并[4,3 - d]嘧啶 - 5 - 基）苯磺酰胺。其通用名称为氨基西地那非。
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