细胞外囊泡在分子诊断学中的应用：以中枢神经系统疾病为例的概述。

Extracellular Vesicles in Molecular Diagnostics: An Overview with a Focus on CNS Diseases.

机构信息

Center for Translational and Applied Neuro-Oncology, University of California, San Diego, CA, United States; Center for Computational Analysis of Social and Organizational Systems, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, United States; University of California, San Diego, CA, United States.

Center for Translational and Applied Neuro-Oncology, University of California, San Diego, CA, United States; University of California, San Diego, CA, United States.

出版信息

Adv Clin Chem. 2016;76:37-53. doi: 10.1016/bs.acc.2016.05.005. Epub 2016 Jul 5.

DOI:10.1016/bs.acc.2016.05.005

PMID:27645815

Abstract

All known cells continuously release nanoscale lipid membrane-enclosed packets. These packets, termed extracellular vesicles (EVs), bear the signature of their cells of origin. These vesicles can be detected in just about every type of biofluid tested, including blood, urine, and cerebrospinal fluid. The majority comes from normal cells, but disease cells also release them. There is a great interest in collecting and analyzing EVs in biofluids as diagnostics for a wide spectrum of central nervous system diseases. Here, we will review the state of central nervous system EV research in terms of molecular diagnostics and biomarkers.

摘要

所有已知的细胞都会持续释放纳米级的脂质膜包裹的囊泡。这些囊泡被称为细胞外囊泡（EVs），携带着它们起源细胞的特征。这些囊泡几乎可以在所有测试的生物流体中被检测到，包括血液、尿液和脑脊液。它们主要来自正常细胞，但疾病细胞也会释放它们。人们对从生物流体中收集和分析 EV 作为广泛的中枢神经系统疾病的诊断方法非常感兴趣。在这里，我们将根据分子诊断和生物标志物来回顾中枢神经系统 EV 研究的现状。