Guo Jiaxian, She Xiangjun, Liu Xiaoying, Sun Xiaodong
Department of Ophthalmology, Shanghai General Hospital, Shanghai, China.
Ophthalmologica. 2017;237(1):21-28. doi: 10.1159/000453112. Epub 2017 Jan 14.
The aim of this study was to evaluate the repeatability and reproducibility of foveal avascular zone (FAZ) area measurements using AngioPlex spectral domain optical coherence tomography (OCT) angiography in normal subjects.
Twenty-two healthy subjects (25 eyes) underwent FAZ area measurements with AngioPlex OCT. Each volunteer was separately examined 3 consecutive times by the 2 experienced observers. The FAZ area was measured using ImageJ software. Intraobserver repeatability was evaluated by calculating the coefficient of variation (CoV) and intraclass correlation coefficient (ICC). Interobserver reproducibility was also assessed using the Bland-Altman test and concordance correlation coefficient (CCC).
The FAZ areas were measured as 0.373 ± 0.109 and 0.377 ± 0.112 mm2 by observers 1 and 2, respectively. The repeatability assessment of the FAZ area measurements yielded CoV values of 0.029 and 0.034 and ICC values of 0.997 and 0.996 by observers 1 and 2, respectively. The mean difference between the 2 observers was 0.004. CCC values ranged from 0.9705 to 0.9844.
The FAZ area measurements obtained using AngioPlex OCT showed a good repeatability and reproducibility in healthy subjects. Excellent reliability makes AngioPlex OCT a valid device for measuring the FAZ area.
本研究旨在评估使用AngioPlex谱域光学相干断层扫描（OCT）血管造影术测量正常受试者黄斑无血管区（FAZ）面积的重复性和再现性。
22名健康受试者（25只眼）接受了AngioPlex OCT测量FAZ面积。每位志愿者由2名经验丰富的观察者分别连续检查3次。使用ImageJ软件测量FAZ面积。通过计算变异系数（CoV）和组内相关系数（ICC）评估观察者内重复性。还使用Bland-Altman检验和一致性相关系数（CCC）评估观察者间再现性。
观察者1和观察者2测量的FAZ面积分别为0.373±0.109和0.377±0.112mm²。观察者1和观察者2对FAZ面积测量的重复性评估得出CoV值分别为0.029和0.034，ICC值分别为0.997和0.996。两名观察者之间的平均差异为0.004。CCC值范围为0.9705至0.9844。
使用AngioPlex OCT获得的FAZ面积测量在健康受试者中显示出良好的重复性和再现性。出色的可靠性使AngioPlex OCT成为测量FAZ面积的有效设备。
