Rhee Jinnie J, Kim Eunjung, Buring Julie E, Kurth Tobias
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts; Division of Aging, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts; Department of Medicine, Division of Nephrology, Stanford University School of Medicine, Palo Alto, California.
Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Am J Prev Med. 2017 Jan;52(1):10-19. doi: 10.1016/j.amepre.2016.07.020. Epub 2016 Sep 16.
Data on omega-3 polyunsaturated fatty acids in relation to cardiovascular disease are limited in women. The aim of this study was to examine longitudinal relations of tuna and dark fish, α-linolenic acid, and marine omega-3 fatty acid intake with incident major cardiovascular disease in women.
This was a prospective cohort study of U.S. women participating in the Women's Health Study from 1993 to 2014, during which the data were collected and analyzed. A total of 39,876 women who were aged ≥45 years and free of cardiovascular disease at baseline provided dietary data on food frequency questionnaires. Analyses used Cox proportional hazards models to evaluate the association between fish and energy-adjusted omega-3 polyunsaturated fatty acid intake and the risk of major cardiovascular disease, defined as a composite outcome of myocardial infarction, stroke, and cardiovascular death, in 38,392 women in the final analytic sample (96%).
During 713,559 person years of follow-up, 1,941 cases of incident major cardiovascular disease were confirmed. Tuna and dark fish intake was not associated with the risk of incident major cardiovascular disease (p-trend >0.05). Neither α-linolenic acid nor marine omega-3 fatty acid intake was associated with major cardiovascular disease or with individual cardiovascular outcomes (all p-trend >0.05). There was no effect modification by age, BMI, or baseline history of hypertension.
In this cohort of women without history of cardiovascular disease, intakes of tuna and dark fish, α-linolenic acid, and marine omega-3 fatty acids were not associated with risk of major cardiovascular disease.
关于ω-3多不饱和脂肪酸与女性心血管疾病关系的数据有限。本研究旨在探讨金枪鱼、深海鱼类、α-亚麻酸和海洋ω-3脂肪酸摄入量与女性新发主要心血管疾病之间的纵向关系。
这是一项对1993年至2014年参与女性健康研究的美国女性进行的前瞻性队列研究，在此期间收集并分析数据。共有39876名年龄≥45岁且基线时无心血管疾病的女性在食物频率问卷上提供了饮食数据。分析使用Cox比例风险模型评估鱼类和能量调整后的ω-3多不饱和脂肪酸摄入量与主要心血管疾病风险之间的关联，主要心血管疾病定义为心肌梗死、中风和心血管死亡的综合结果，最终分析样本中的38392名女性（96%）参与了研究。
在713559人年的随访期间，确诊了1941例新发主要心血管疾病病例。金枪鱼和深海鱼类摄入量与新发主要心血管疾病风险无关（P趋势>0.05）。α-亚麻酸和海洋ω-3脂肪酸摄入量均与主要心血管疾病或个体心血管结局无关（所有P趋势>0.05）。年龄、体重指数或高血压基线病史均未产生效应修饰作用。
在这个无心血管疾病病史的女性队列中，金枪鱼、深海鱼类、α-亚麻酸和海洋ω-3脂肪酸的摄入量与主要心血管疾病风险无关。
