Yamada Yasushi, Ohira Satoshi, Yamazaki Teruyuki, Shiozawa Tanri
Department of Obstetrics and Gynecology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan.
Department of Obstetrics and Gynecology, Iida Municipal Hospital, 438 Yawatamachi, Iida 395-8502, Japan.
Case Rep Obstet Gynecol. 2016;2016:7618631. doi: 10.1155/2016/7618631. Epub 2016 Aug 25.
Ectopic molar pregnancy is extremely rare, and preoperative diagnosis is difficult. Our literature search found only one report of molar pregnancy diagnosed preoperatively. Moreover, there is no English literature depicting magnetic resonance image (MRI) findings of ectopic molar pregnancy. We report a case of ectopic molar pregnancy preoperatively diagnosed using MRI. A literature review of 31 cases of ectopic molar pregnancy demonstrated that lesions have been found in the fallopian tube (19 cases, 61%), ovary (5 cases, 16%), cornu (3 cases, 10%), peritoneum (2 cases, 6%), uterine cervix (1 case, 3%), and cesarean scar (1 case, 3%). Abdominal pain and abnormal vaginal bleeding were reported in 70% and 61% of the patients, respectively. Twenty-one cases (67%) presented with rupture and hemoperitoneum. All patients underwent surgical resection or dilatation and curettage. Methotrexate therapy was performed in one case because residual trophoblastic tissue was suspected. A second operation was performed in one case of ovarian molar pregnancy because serum hCG levels increased again after primary focal ovarian resection. No patients developed metastatic disease or relapsed. These findings suggest the prognosis of ectopic molar pregnancy to be favorable.
异位葡萄胎妊娠极为罕见,术前诊断困难。我们的文献检索仅发现一篇术前诊断为葡萄胎妊娠的报告。此外,尚无英文文献描述异位葡萄胎妊娠的磁共振成像(MRI)表现。我们报告一例术前通过MRI诊断的异位葡萄胎妊娠病例。对31例异位葡萄胎妊娠病例的文献回顾表明,病变见于输卵管(19例,61%)、卵巢(5例,16%)、宫角(3例,10%)、腹膜(2例,6%)、子宫颈(1例,3%)和剖宫产瘢痕(1例,3%)。分别有70%和61%的患者报告有腹痛和异常阴道出血。21例(67%)出现破裂和腹腔积血。所有患者均接受了手术切除或刮宫术。1例因怀疑有残留滋养层组织而进行了甲氨蝶呤治疗。1例卵巢葡萄胎妊娠患者在初次局部卵巢切除术后血清hCG水平再次升高,因此进行了二次手术。无患者发生转移性疾病或复发。这些发现提示异位葡萄胎妊娠的预后良好。