de Aquino Favarato Grace Kelly Naves, da Silva Aline Cristina Souza, Oliveira Lívia Ferreira, da Fonseca Ferraz Mara Lúcia, de Paula Antunes Teixeira Vicente, Cavellani Camila Lourencini
Biological and Natural Science Institute, General Pathology Discipline, Triângulo Mineiro Federal University (UFTM), Uberaba, MG, Brazil.
Biological and Natural Science Institute, General Pathology Discipline, Triângulo Mineiro Federal University (UFTM), Uberaba, MG, Brazil.
Ann Diagn Pathol. 2016 Oct;24:35-9. doi: 10.1016/j.anndiagpath.2016.07.004. Epub 2016 Aug 12.
To evaluate the histomorphometric skin changes over aging patients with autopsied acquired immunodeficiency syndrome (AIDS). In 29 skin fragments of autopsied elderly (older than 50 years) and nonelderly patients with AIDS, epidermal thickness, the number of layers, the diameter of cells, the percentage of collagen and elastic fibers in the dermis, and the number and morphology of Langerhans cells were assessed. Statistical analysis was performed by SigmaStat 2.03 program. The thickness of the epidermis (92.55 × 158.94 μm), the number of layers (7 × 9 layers), and the diameter of the cells (13.27 × 17.6 μm) were statistically lower among the elderly. The quantity of collagen fibers (9.68 × 14.11%) and elastic fibers (11.89 × 15.31%) was also significantly lower in the elderly. There was a decrease in total (10.61 × 12.38 cel/mm(2)) and an increase in immature Langerhans cells (6.31 × 4.98 cel/mm(2)) in elderly patients with AIDS. The aging of the skin of patients with AIDS is amended in different histomorphometric aspects, the epidermis constituents suffer less pronounced changes in normal aging, and the dermis has more intense changes in elastic fibers and collagen.
评估尸检获得性免疫缺陷综合征（AIDS）老年患者的皮肤组织形态计量学变化。对29例尸检的老年（年龄大于50岁）和非老年AIDS患者的皮肤碎片进行研究，评估表皮厚度、层数、细胞直径、真皮中胶原纤维和弹性纤维的百分比以及朗格汉斯细胞的数量和形态。采用SigmaStat 2.03软件进行统计分析。老年患者的表皮厚度（92.55×158.94μm）、层数（7×9层）和细胞直径（13.27×17.6μm）在统计学上较低。老年患者的胶原纤维数量（9.68×14.11%）和弹性纤维数量（11.89×15.31%）也显著较低。老年AIDS患者的朗格汉斯细胞总数减少（10.61×12.38个细胞/mm²），未成熟朗格汉斯细胞数量增加（6.31×4.98个细胞/mm²）。AIDS患者皮肤的老化在不同组织形态计量学方面有所改变，表皮成分在正常老化中变化不明显，真皮的弹性纤维和胶原纤维变化更明显。
