Research Institute of Orthopedics, The Affiliated Jiangnan Hospital of Zhejiang Chinese Medical University, Hangzhou, 312001, Zhejiang, China.
Hangzhou Xiaoshan Hospital of Traditional Chinese Medicine, Hangzhou, 312001, Zhejiang, China.
J Orthop Surg Res. 2023 May 22;18(1):376. doi: 10.1186/s13018-023-03785-7.
There is very limited of evidence linking fibrinogen and bone mineral density (BMD) in postmenopausal women. Therefore, this study intended to examine the relationship between fibrinogen and total BMD in postmenopausal women.
This cross-sectional analysis included 2043 postmenopausal women aged 50 years and older from the 1999 to 2002 National Health and Nutrition Examination Survey. The independent variable was fibrinogen and the outcome variable was total BMD. The association between fibrinogen and total BMD in postmenopausal women was examined using multivariate linear regression models, with subgroup analyses stratified by race. Smoothing curve fitting and generalized additive models further analyzed the sample data.
In multiple regression models adjusted for potential confounders, fibrinogen was negatively associated with total BMD (model 1: - 0.0002 [- 0.0002, - 0.0001], model 2: - 0.0000 [- 0.0001, - 0.0000], model 3: - 0.0001 [- 0.0001, - 0.0001]). In subgroup analysis stratified by race, fibrinogen levels were negatively associated with total BMD in postmenopausal women, Non-Hispanic Whites, and Mexican Americans. However, in Non-Hispanic Blacks, the correlation between fibrinogen levels and total BMD was not significant. For individuals that identify as Other Races, fibrinogen levels were positively correlated with total BMD.
Our findings show a negative association between fibrinogen levels and total BMD in most postmenopausal women aged 50 years and older, however, is variable by race. In postmenopausal women, Non-Hispanic Whites and Mexican Americans, relatively high fibrinogen levels may be adverse to bone health.
仅有有限的证据表明纤维蛋白原与绝经后妇女的骨密度（BMD）有关。因此，本研究旨在研究纤维蛋白原与绝经后妇女总 BMD 之间的关系。
本横断面分析纳入了 1999 年至 2002 年全国健康和营养调查中 2043 名年龄在 50 岁及以上的绝经后妇女。自变量为纤维蛋白原，因变量为总 BMD。使用多元线性回归模型，按种族分层进行亚组分析，研究纤维蛋白原与绝经后妇女总 BMD 之间的关系。平滑曲线拟合和广义加性模型进一步分析了样本数据。
在调整了潜在混杂因素的多变量回归模型中，纤维蛋白原与总 BMD 呈负相关（模型 1：-0.0002[-0.0002，-0.0001]，模型 2：-0.0000[-0.0001，-0.0000]，模型 3：-0.0001[-0.0001，-0.0001]）。按种族分层的亚组分析显示，纤维蛋白原水平与绝经后妇女、非西班牙裔白人和墨西哥裔美国人的总 BMD 呈负相关。然而，在非西班牙裔黑人中，纤维蛋白原水平与总 BMD 之间的相关性不显著。对于其他种族的个体，纤维蛋白原水平与总 BMD 呈正相关。
我们的研究结果表明，在大多数年龄在 50 岁及以上的绝经后妇女中，纤维蛋白原水平与总 BMD 呈负相关，但与种族有关。在绝经后妇女中，非西班牙裔白人和墨西哥裔美国人中，相对较高的纤维蛋白原水平可能对骨骼健康不利。
