Rajagopal Senthilkumar, Sangam Supraj Raja, Singh Shubham, Joginapally Venkateswara Rao
Department of Zoology, Nizam College, Hyderabad, India.
Adv Neurobiol. 2016;12:401-14. doi: 10.1007/978-3-319-28383-8_22.
Proteins are playing a vital role in maintaining the cellular integrity and function, as well as for brain cells. Protein intake and supplementation of individual amino acids can affect the brain functioning and mental health, and many of the neurotransmitters in the brain are made from amino acids. The amino acid supplementation has been found to reduce symptoms, as they are converted into neurotransmitters which in turn extenuate the mental disorders. The biosynthesis of amino acids in the brain is regulated by the concentration of amino acids in plasma. The brain diseases such as depression, bipolar disorder, schizophrenia, obsessive-compulsive disorder (OCD), and Alzheimer's (AD), Parkinson's (PD), and Huntington's diseases (HD) are the most common mental disorders that are currently widespread in numerous countries. The intricate biochemical and molecular machinery contributing to the neurological disorders is still unknown, and in this chapter, we revealed the involvement of dietary amino acids on neurological diseases.
蛋白质在维持细胞完整性和功能方面发挥着至关重要的作用，对脑细胞也是如此。蛋白质摄入和个别氨基酸的补充会影响大脑功能和心理健康，并且大脑中的许多神经递质都是由氨基酸制成的。已发现补充氨基酸可减轻症状，因为它们会转化为神经递质，进而减轻精神障碍。大脑中氨基酸的生物合成受血浆中氨基酸浓度的调节。诸如抑郁症、双相情感障碍、精神分裂症、强迫症（OCD）以及阿尔茨海默病（AD）、帕金森病（PD）和亨廷顿舞蹈病（HD）等脑部疾病是目前在许多国家广泛存在的最常见精神障碍。导致神经疾病的复杂生化和分子机制仍然未知，在本章中，我们揭示了膳食氨基酸与神经疾病的关联。
