Elumalai Preetham, Lakshmi Sreeja
Kerala University of Fisheries and Ocean Studies, Panangad, Cochin, Kerala, India.
Adv Neurobiol. 2016;12:229-45. doi: 10.1007/978-3-319-28383-8_12.
Neurodegenerative disorders are often life threatening and hired as an economic burden to the health-care system. Nutritional interventions principally involving polyphenols were practiced to arrest or reverse the age-related health disorders. Flavonoids, a class of dietary polyphenols, are rising to superstardom in preventing brain disorders with their potent antioxidant defense mechanism. Quercetin is a ubiquitous flavonoid reported to have all-natural myriad of health benefits. Citrus fruits, apple, onion, parsley, berries, green tea, and red wine comprise the major dietary supplements of quercetin apart from some herbal remedies like Ginkgo biloba. Appositeness of quercetin in reducing risks of neurodegenerative disorders, cancer, cardiovascular diseases, allergic disorders, thrombosis, atherosclerosis, hypertension, and arrhythmia, to name a few, is attributed to its highly pronounced antioxidant and anti-inflammatory properties. Neurodegeneration, characterized by progressive deterioration of the structure and function of neurons, is crucially accompanied by severe cognitive deficits. Aging is the major risk factor for neurodegenerative disorders in Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD) being coequal high hands. Oxidative stress and mitochondrial dysfunction are the key players in triggering neurodegeneration. The upsurge of neurodegenerative disorders is always appalling since there exists a paucity in effective treatment practices. Past few years' studies have underpinned the mechanisms through which quercetin boons the brain health in many aspects including betterment in cognitive output. Undoubtedly, quercetin will be escalating as an arable field, both in scientific research and in pharmacological and clinical applications.
神经退行性疾病往往危及生命，并给医疗保健系统带来经济负担。人们采用主要涉及多酚的营养干预措施来阻止或逆转与年龄相关的健康问题。黄酮类化合物是一类膳食多酚，凭借其强大的抗氧化防御机制，在预防脑部疾病方面正崭露头角。槲皮素是一种普遍存在的黄酮类化合物，据报道具有各种各样的天然健康益处。柑橘类水果、苹果、洋葱、欧芹、浆果、绿茶和红酒是槲皮素的主要膳食来源，此外还有一些草药，如银杏。槲皮素在降低神经退行性疾病、癌症、心血管疾病、过敏性疾病、血栓形成、动脉粥样硬化、高血压和心律失常等疾病风险方面的适用性，归因于其高度显著的抗氧化和抗炎特性。神经退行性变的特征是神经元结构和功能的逐渐恶化，严重的认知缺陷是其关键伴随症状。衰老 是阿尔茨海默病（AD）、帕金森病（PD）和亨廷顿病（HD）等神经退行性疾病的主要危险因素。氧化应激和线粒体功能障碍是引发神经退行性变的关键因素。由于有效治疗方法匮乏，神经退行性疾病的激增一直令人震惊。过去几年的研究揭示了槲皮素在许多方面改善大脑健康的机制，包括提高认知能力。毫无疑问，槲皮素在科学研究以及药理和临床应用方面都将成为一个有前景的领域。
