Blackburn J R, Phillips A G, Fibiger H C
University of British Columbia, Vancouver, Canada.
Behav Neurosci. 1989 Aug;103(4):903-6. doi: 10.1037//0735-7044.103.4.903.
The effects of metoclopramide and thioridazine on feeding behaviors of male hooded rats were investigated in 2 experiments. Metoclopramide (2.5-7.5 mg/kg) attenuated conditioned preparatory responses to a conditional stimulus signaling delivery of a meal. However, consummatory responses were affected only by the highest dose. Similar effects had previously been observed following administration of pimozide (Blackburn, Phillips, & Fibiger, 1987). Thioridazine (10-30 mg/kg) had no significant effect on any measure of feeding behavior. The different effects of the 2 drugs may be related to their preferential actions at dopamine terminals in anatomically distinct regions of the forebrain.
在两项实验中研究了胃复安和硫利达嗪对雄性带帽大鼠进食行为的影响。胃复安（2.5 - 7.5毫克/千克）减弱了对预示进餐的条件刺激的条件性准备反应。然而，只有最高剂量才会影响进食反应。之前在给予匹莫齐特后也观察到了类似的效果（布莱克本、菲利普斯和菲比格，1987年）。硫利达嗪（10 - 30毫克/千克）对任何进食行为指标均无显著影响。这两种药物的不同效果可能与其在前脑解剖学上不同区域的多巴胺末梢的优先作用有关。
