Blackburn J R, Phillips A G, Fibiger H C
Behav Neurosci. 1987 Jun;101(3):352-60. doi: 10.1037//0735-7044.101.3.352.
The involvement of dopaminergic systems in appetitive and ingestive feeding behaviors was investigated in two experiments. Conditioned preparatory responses to a conditional stimulus (CS+) signaling delivery of a meal were attenuated in rats by doses of 0.4 and 0.6 mg/kg of the dopamine receptor antagonist pimozide. In contrast, animals responded in a normal fashion following the delivery of food. Similarly, in a separate study, the 20-min free-feeding intake of liquid diet by rats that had been deprived of food for 23 hr was unaffected by doses of pimozide as high as 0.6 mg/kg. These findings are consistent with the involvement of dopamine in the production of preparatory behaviors elicited by incentive stimuli.
在两项实验中研究了多巴胺能系统在食欲性和摄食性进食行为中的作用。给予大鼠0.4毫克/千克和0.6毫克/千克剂量的多巴胺受体拮抗剂匹莫齐特后，对预示进食的条件刺激（CS+）的条件性准备反应减弱。相比之下，给予食物后动物的反应正常。同样，在另一项研究中，禁食23小时的大鼠在20分钟内自由摄入流质食物的量不受高达0.6毫克/千克剂量匹莫齐特的影响。这些发现与多巴胺参与由激励刺激引发的准备行为的产生一致。
