Nagasaka Yosuke, Ito Yasuki, Ueno Shinji, Terasaki Hiroko
Department of Ophthalmology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, Japan.
Sci Rep. 2016 Sep 22;6:33921. doi: 10.1038/srep33921.
Retinitis pigmentosa(RP) is a hereditary retinal disease that causes photoreceptor, outer retinal, degeneration. Although the pathogenesis is still unclear, there have been numerous reports regarding inner retinal changes in RP eyes. The aim of this study is to retrospectively evaluate the changes in the thicknesses of different retinal layers of RP eyes, and its association with aqueous flare, which is used for measuring the intensity of intraocular inflammation. A total of 125 eyes of 64 patients with RP and 13 normal eyes were studied. The thicknesses of total neural retina,nerve fiber layer(NFL),ganglion cell layer(GCL),inner plexiform layer(IPL),inner nuclear layer(INL),outer layers and foveal thickness were measured in the optical coherence tomographic images. Aqueous flare was measured with a laser flare-cell meter. The associations between those parameters, visual acuity and visual field were determined in RP eyes using multivariate analysis. The results of this study showed the significant thickening of NFL, GCL and INL, the significant thinning of outer layers and the association of them with increased aqueous flare, whereas NFL and INL thickening associated with outer retinal thinning. These results can suggest the involvement of intraocular inflammation in the pathogenesis of inner retinal thickening as a secondary change following outer retinal degeneration.
视网膜色素变性（RP）是一种遗传性视网膜疾病，可导致光感受器、视网膜外层发生变性。尽管其发病机制尚不清楚，但已有许多关于RP患者眼内视网膜内层变化的报道。本研究的目的是回顾性评估RP患者眼内不同视网膜层厚度的变化，及其与用于测量眼内炎症强度的房水闪光的相关性。共研究了64例RP患者的125只眼和13只正常眼。在光学相干断层扫描图像中测量了全神经视网膜、神经纤维层（NFL）、神经节细胞层（GCL）、内网状层（IPL）、内核层（INL）、外层和黄斑厚度。使用激光闪光细胞仪测量房水闪光。在RP患者眼中，通过多变量分析确定了这些参数、视力和视野之间的相关性。本研究结果显示，NFL、GCL和INL显著增厚，外层显著变薄，且它们与房水闪光增加有关，而NFL和INL增厚与视网膜外层变薄有关。这些结果提示，眼内炎症参与了视网膜外层变性继发的视网膜内层增厚的发病机制。
