生发中心围绕Bcl6循环以增强B细胞免疫。
Looping around Bcl6 in Germinal Center to Sharpen B Cell Immunity.
作者信息
Hu Gangqing, Zhao Keji
机构信息
Systems Biology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA.
Systems Biology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA.
出版信息
Immunity. 2016 Sep 20;45(3):459-461. doi: 10.1016/j.immuni.2016.08.020.
Abstract
We are beginning to understand the function of 3D genome architecture in the immune system. In this issue, Bunting et al. (2016) reported massive multi-layer genome reorganization from naive B cells to germinal center B cells, centered on a locus control region of Bcl6.
摘要
我们开始了解三维基因组结构在免疫系统中的功能。在本期中，邦廷等人（2016年）报道了从初始B细胞到生发中心B细胞的大规模多层基因组重组，其核心是Bcl6的一个基因座控制区。
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2
The second decade of 3C technologies: detailed insights into nuclear organization.3C技术的第二个十年：对细胞核组织的深入洞察
Genes Dev. 2016 Jun 15;30(12):1357-82. doi: 10.1101/gad.281964.116.
3
Chromatin Domains: The Unit of Chromosome Organization.染色质结构域：染色体组织的单位
Mol Cell. 2016 Jun 2;62(5):668-80. doi: 10.1016/j.molcel.2016.05.018.
4
"Cat's Cradling" the 3D Genome by the Act of LncRNA Transcription.“长链非编码 RNA 转录”对三维基因组的“套索”作用。
Mol Cell. 2016 Jun 2;62(5):657-64. doi: 10.1016/j.molcel.2016.05.011.
5
Dynamic Reorganization of Extremely Long-Range Promoter-Promoter Interactions between Two States of Pluripotency.胚胎两种状态下超长距离启动子-启动子相互作用的动态重排。
Cell Stem Cell. 2015 Dec 3;17(6):748-757. doi: 10.1016/j.stem.2015.11.010.
6
Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation.小鼠基因调控区域互作组图谱揭示了转录调控的基本原理。
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7
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Nat Immunol. 2012 Dec;13(12):1196-204. doi: 10.1038/ni.2432. Epub 2012 Oct 14.
8
Characterization of genome-wide enhancer-promoter interactions reveals co-expression of interacting genes and modes of higher order chromatin organization.全基因组增强子-启动子相互作用的特征分析揭示了相互作用基因的共表达和更高阶染色质组织的模式。
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9
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