Honjo K, Doi K, Doi C, Mitsuoka T
Lab Anim. 1986 Oct;20(4):298-303. doi: 10.1258/002367786780808695.
Histopathological examinations were carried out on female DBA/2N and CD-1 mice which were autopsied 4 and 12 weeks after six daily intraperitoneal injections of streptozotocin (SZ). Histopathological changes related to SZ treatment were found in the pancreas, liver and kidneys. Little difference was observed between the two strains in the histological changes of the pancreas (a decrease in size of the islets, and degranulation and a decrease in the number of B cells) and liver (hypertrophy of hepatocytes and cytoplasmic invagination into hepatocyte nuclei). With regard to the changes in the kidneys, DBA/2N mice showed characteristic inclusions positive to periodic acid-Schiff reagent in the distal tubule epithelial cells, while CD-1 mice showed remarkable luminal dilatation and epithelial cell deformation of distal tubules. SZ-induced diabetes had no influence on the development of spontaneous cardiovascular lesions in DBA/2N mice under the present experimental conditions.
对雌性DBA/2N和CD-1小鼠进行了组织病理学检查，这些小鼠在连续6天腹腔注射链脲佐菌素（SZ）后4周和12周进行了尸检。在胰腺、肝脏和肾脏中发现了与SZ治疗相关的组织病理学变化。在胰腺（胰岛大小减小、B细胞脱颗粒和数量减少）和肝脏（肝细胞肥大以及细胞质内陷进入肝细胞核）的组织学变化方面，两种品系之间观察到的差异很小。关于肾脏的变化，DBA/2N小鼠在远端小管上皮细胞中显示出对过碘酸希夫试剂呈阳性的特征性包涵体，而CD-1小鼠则显示出远端小管明显的管腔扩张和上皮细胞变形。在本实验条件下，SZ诱导的糖尿病对DBA/2N小鼠自发性心血管病变的发展没有影响。
