Tokuchi Ryo, Hishikawa Nozomi, Sato Kota, Hatanaka Noriko, Fukui Yusuke, Takemoto Mami, Ohta Yasuyuki, Yamashita Toru, Abe Koji
Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan; Department of Occupational Therapy, Okayama Institute for Medical and Technical Sciences, Japan.
Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.
J Neurol Sci. 2016 Oct 15;369:278-282. doi: 10.1016/j.jns.2016.08.053. Epub 2016 Aug 25.
We compared the behavioral and psychological symptoms of Alzheimer's disease (AD) and Parkinson's disease (PD) in order to determine the characteristic features of each disorder.
For this retrospective cohort study, we compared the behavioral and psychological symptoms of 288AD patients and 189 PD patients (mean age, 74.6±5.9 and 73.0±8.7years respectively). Symptoms were evaluated using the geriatric depression scale (GDS), apathy scale (AS), and Abe's behavioral and psychological symptoms of dementia score (ABS).
AD patients had higher AS and ABS scores than PD patients. A gender-dependent comparison showed that ABS scores were worse in female AD patients than in female PD patients (p=0.001). A subscale analysis of ABS scores revealed that male AD patients were only significantly different from male PD patients in 1 item, whereas female AD patients were significantly different from female PD patients in 4 items. Among patients with mild cognitive decline, no differences in affective scores were observed. Alternatively, among patients with moderate cognitive decline, affective scores on all 3 scales were worse in PD patients than in AD patients.
The present age- and gender-matched retrospective analysis identified greater behavioral and psychological disease severity in female AD patients relative to female PD patients, and greater affective severity in PD patients versus AD patients with a similar degree of cognitive decline.
我们比较了阿尔茨海默病（AD）和帕金森病（PD）的行为和心理症状，以确定每种疾病的特征。
在这项回顾性队列研究中，我们比较了288例AD患者和189例PD患者（平均年龄分别为74.6±5.9岁和73.0±8.7岁）的行为和心理症状。使用老年抑郁量表（GDS）、淡漠量表（AS）和阿部痴呆行为和心理症状评分（ABS）对症状进行评估。
AD患者的AS和ABS评分高于PD患者。一项基于性别的比较显示，女性AD患者的ABS评分比女性PD患者更差（p = 0.001）。对ABS评分的子量表分析显示，男性AD患者与男性PD患者仅在1项上有显著差异，而女性AD患者与女性PD患者在4项上有显著差异。在轻度认知功能减退的患者中，未观察到情感评分的差异。相反，在中度认知功能减退的患者中，PD患者在所有3个量表上的情感评分比AD患者更差。
本次年龄和性别匹配的回顾性分析发现，相对于女性PD患者，女性AD患者的行为和心理疾病严重程度更高；在认知功能减退程度相似的情况下，PD患者的情感严重程度高于AD患者。
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