Exercise Physiology Laboratory, Faculty of Nursing and Human Nutrition, Yamaguchi Prefectural University, 6-2-1 Sakurabatake, Yamaguchi, 753-0021, Japan.
Department of Exercise and Health Science, Faculty of Education, University of Yamaguchi, Yamaguchi, Japan.
J Physiol Sci. 2017 Mar;67(2):331-337. doi: 10.1007/s12576-016-0488-6. Epub 2016 Sep 22.
To test the hypothesis that topical menthol-induced reactivity of cold sensation and cutaneous vasoconstriction to local cooling is augmented in individuals with a cold constitution, we examined thermal sensation and cutaneous vasoconstrictor responses at menthol-treated and untreated sites in the legs during local skin cooling in young women complaining of chilliness (C group) and young women with no complaint as a normal control group (N group). During local skin cooling, the sensitivity to cold sensation was greater in the C group than in the N group. The application of menthol enhanced the cold sensation at a low temperature in the N group, but not in the C group. Cutaneous vasoconstrictor responses to local skin cooling were not altered by menthol treatment in either of the two groups. These findings suggest the desensitization of menthol-activated cold receptors in the legs of C group subjects, and a minor role of cold receptor activity in cutaneous vasoconstrictor response to local cooling.
为了验证这样一种假设，即局部薄荷醇诱导的冷感觉和皮肤血管收缩对局部冷却的反应性在体质寒冷的个体中增强，我们在抱怨发冷的年轻女性（C 组）和没有抱怨的年轻女性腿部的薄荷醇处理和未处理部位，在局部皮肤冷却时检查了热感觉和皮肤血管收缩器反应作为正常对照组（N 组）。在局部皮肤冷却期间，C 组对冷感觉的敏感性大于 N 组。薄荷醇的应用增强了 N 组在低温下的冷感觉，但在 C 组中没有。两组中薄荷醇处理均未改变局部皮肤冷却引起的皮肤血管收缩反应。这些发现表明 C 组受试者腿部的薄荷醇激活冷受体脱敏，以及冷受体活性在局部冷却引起的皮肤血管收缩反应中的次要作用。
