Tian Jiaxing, Lian Fengmei, Yu Xiaotong, Cui Yashan, Zhao Tianyu, Cao Yang, Tong Xiaolin
Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China; Beijing University of Chinese Medicine, Beijing 100029, China.
Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
Evid Based Complement Alternat Med. 2016;2016:5473015. doi: 10.1155/2016/5473015. Epub 2016 Aug 30.
Background. The study was designed to assess the efficacy and safety of Chinese herbal decoction in treating outpatients with T2DM. Methods. All patients enrolled received decoction for at least 6 months. The primary outcome was the control rate of HbA1c and the change in HbA1c. FPG, 2hPG, HOMA-IR, and HOMA-β were also collected and evaluated. Results. The control rates after treatment at months 6, 12, 18, 24, 36, 48, and 60 were 45.07%, 52.78%, 47.22%, 45.83%, 50.00%, 57.14%, and 40.00%. Multiple linear regression showed the change of HbA1c has a significant relationship with the baseline HbA1c and duration of DM and BMI (p < 0.05). Both FPG and 2hPG levels significantly decreased compared to the baseline (p < 0.05). Chinese herbal decoction also improved islet cell function with decreased HOMA-IR and increased HOMA-β (p < 0.05). 19 and 4 subjects deactivated the antidiabetes drugs or insulin, respectively, after taking decoction. One subject developed DKD and one developed DPN, and another subject showed abnormal liver function which was irrelevant to decoction treatment. Conclusions. Chinese herbal decoction significantly enhanced the hypoglycemic action and had certain effect on protecting islet cell function. As a candidate diabetes therapy, it may reduce the use of antidiabetes drugs and slow the progression to diabetes complications.
背景。本研究旨在评估中药汤剂治疗2型糖尿病门诊患者的疗效和安全性。方法。所有纳入的患者均接受汤剂治疗至少6个月。主要结局是糖化血红蛋白（HbA1c）的控制率和HbA1c的变化。还收集并评估了空腹血糖（FPG）、餐后2小时血糖（2hPG）、胰岛素抵抗指数（HOMA-IR）和胰岛β细胞功能指数（HOMA-β）。结果。治疗6、12、18、24、36、48和60个月后的控制率分别为45.07%、52.78%、47.22%、45.83%、50.00%、57.14%和40.00%。多元线性回归显示，HbA1c的变化与基线HbA1c、糖尿病病程和体重指数（BMI）有显著关系（p<0.05）。与基线相比，FPG和2hPG水平均显著降低（p<0.05）。中药汤剂还改善了胰岛细胞功能，HOMA-IR降低，HOMA-β升高（p<0.05）。19名和4名受试者在服用汤剂后分别停用了抗糖尿病药物或胰岛素。1名受试者发生糖尿病肾病（DKD），1名发生糖尿病周围神经病变（DPN），另1名受试者肝功能异常，与汤剂治疗无关。结论。中药汤剂显著增强了降糖作用，对保护胰岛细胞功能有一定作用。作为一种候选的糖尿病治疗方法，它可能减少抗糖尿病药物的使用，并减缓糖尿病并发症的进展。
