CD147通过调控K562/ADR白血病细胞系中P-糖蛋白的表达参与多药耐药。
Involvement of CD147 on multidrug resistance through the regulation of P-glycoprotein expression in K562/ADR leukemic cell line.
作者信息
Somno Aoranit, Anuchapreeda Songyot, Chruewkamlow Nuttapol, Pata Supansa, Kasinrerk Watchara, Chiampanichayakul Sawitree
机构信息
Division of Clinical Microscopy, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
Biomedical Technology Research Center, National Center for Genetic Engineering and Biotechnology, National Sciences and Technology Development Agency at the Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
出版信息
Leuk Res Rep. 2016 Aug 26;6:33-8. doi: 10.1016/j.lrr.2016.08.001. eCollection 2016.
The relationship between P-gp and CD147 in the regulation of MDR in leukemic cells has not been reported. This study aimed to investigate the correlation between CD147 and P-gp in the regulation of drug resistance in the K562/ADR leukemic cell line. The results showed that drug-resistant K562/ADR cells expressed significantly higher P-gp and CD147 levels than drug-free K562/ADR cells. To determine the regulatory effect of CD147 on P-gp expression, anti-CD147 antibody MEM-M6/6 significantly decreased P-gp and CD147 mRNA and protein levels. This is the first report to show that CD147 mediates MDR in leukemia through the regulation of P-gp expression.
P-糖蛋白（P-gp）与CD147在白血病细胞多药耐药（MDR）调控中的关系尚未见报道。本研究旨在探讨K562/ADR白血病细胞系中CD147与P-gp在耐药调控中的相关性。结果显示，耐药的K562/ADR细胞中P-gp和CD147的表达水平显著高于无药的K562/ADR细胞。为确定CD147对P-gp表达的调控作用，抗CD147抗体MEM-M6/6显著降低了P-gp和CD147的mRNA及蛋白水平。这是首次报道CD147通过调控P-gp表达介导白血病中的多药耐药。
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