曲霉内酯L和M，来自内生真菌杂色曲霉的新型丁内酯。
Aspernolides L and M, new butyrolactones from the endophytic fungus Aspergillus versicolor.
作者信息
Ibrahim Sabrin R M, Mohamed Gamal A, Ross Samir A
机构信息
Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al Madinah Al Munawwarah 30078, Saudi Arabia, Phone: +966 581183034, E-mail:
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.
出版信息
Z Naturforsch C J Biosci. 2017 May 1;72(5-6):155-160. doi: 10.1515/znc-2016-0138.
During the systematic search of active compounds from endophytic fungi, two new butyrolactones, namely aspernolides L (2) and M (4), together with four known compounds: 1-O-acetylglycerol (1), butyrolactone I (3), butyrolactone VI (5), and (+) alantrypinone (6) were characterized from the EtOAc extract of the endophytic fungus Aspergillus versicolor isolated from the roots of Pulicaria crispa (Asteraceae). Extensive spectroscopic analysis, including 1D, 2D NMR, and HRESIMS, was used to elucidate their structures. Compounds 1, 5, and 6 are reported for the first time from this fungus.
在从内生真菌中系统搜索活性化合物的过程中，从菊科植物皱波角果藜根部分离得到的内生真菌杂色曲霉的乙酸乙酯提取物中，鉴定出了两种新的丁内酯，即aspernolides L（2）和M（4），以及四种已知化合物：1-O-乙酰甘油（1）、丁内酯I（3）、丁内酯VI（5）和（+）alantrypinone（6）。通过广泛的光谱分析，包括一维、二维核磁共振和高分辨电喷雾电离质谱，对它们的结构进行了阐明。化合物1、5和6首次从该真菌中报道。
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