Guo Feng, Li Zhanlin, Xu Xiangwei, Wang Kaibo, Shao Meili, Zhao Feng, Wang Haifeng, Hua Huiming, Pei Yuehu, Bai Jiao
Key Laboratory of Structure-Based Drug Design and Discovery, Shenyang Pharmaceutical University, Ministry of Education, Shenyang 110016, PR China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264005, PR China.
Fitoterapia. 2016 Sep;113:44-50. doi: 10.1016/j.fitote.2016.06.014. Epub 2016 Jun 28.
Three new butenolides containing 5-hydroxyfuran-2(5H)-one core, asperteretal A (1), asperteretal B (2), and asperteretal C (3), together with seven known butenolides (4-10), were obtained from an endophytic fungus Aspergillus terreus PR-P-2 isolated from the plant Camellia sinensis var. assamica. The structures of compounds 1-3 were elucidated on the basis of detailed spectroscopic analysis including UV, IR, HRESIMS, 1D and 2D NMR, and ECD spectra. Compounds 1, 3, 5 and 6-8 showed potent inhibitory effects on NO production in RAW 264.7 lipopolysaccharide-induced macrophages, and compounds 5 and 8 also exhibited moderate cytotoxicity against HL-60 cell line.
从从茶树变种阿萨姆茶中分离出的一株内生真菌土曲霉PR-P-2中获得了三种新的含5-羟基呋喃-2(5H)-酮核心的丁烯内酯，asperteretal A（1）、asperteretal B（2）和asperteretal C（3），以及七种已知的丁烯内酯（4-10）。通过包括紫外、红外、高分辨电喷雾电离质谱、一维和二维核磁共振以及电子圆二色光谱在内的详细光谱分析确定了化合物1-3的结构。化合物1、3、5和6-8对RAW 264.7脂多糖诱导的巨噬细胞中一氧化氮的产生具有显著抑制作用，化合物5和8对HL-60细胞系也表现出中等程度的细胞毒性。
