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二氧化锆种植体钻的生物学评价

Biological Evaluation of Implant Drill Made from Zirconium Dioxide.

作者信息

Akiba Yosuke, Eguchi Kaori, Akiba Nami, Uoshima Katsumi

机构信息

Division of Bio-prosthodontics, Department of Oral Health Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

出版信息

Clin Implant Dent Relat Res. 2017 Apr;19(2):306-315. doi: 10.1111/cid.12452. Epub 2016 Sep 22.

Abstract

PURPOSE

Zirconia is a good candidate material in the dental field. In this study, we evaluated biological responses against a zirconia drill using a bone cavity healing model.

MATERIALS AND METHODS

Zirconia drills, stainless steel drills, and the drilled bone surface were observed by scanning electron microscopy (SEM), before and after cavity preparation. For the bone cavity healing model, the upper first and second molars of Wistar rats were extracted. After 4 weeks, cavities were prepared with zirconia drills on the left side. As a control, a stainless steel drill was used on the right side. At 3, 7, and 14 days after surgery, micro-CT images were taken. Samples were prepared for histological staining.

RESULTS

SEM images revealed that zirconia drills maintained sharpness even after 30 drilling procedures. The bone surface was smoother with the zirconia drill. Micro-CT images showed faster and earlier bone healing in the zirconia drill cavity. On H-E staining, at 7 days, the zirconia drill defect had a smaller blank lacunae area. At 14 days, the zirconia drill defect was filled with newly formed bone.

CONCLUSIONS

The zirconia drill induces less damage during cavity preparation and is advantageous for bone healing. (197 words).

摘要

目的

氧化锆是牙科领域一种理想的候选材料。在本研究中,我们使用骨腔愈合模型评估了针对氧化锆钻的生物学反应。

材料与方法

在制备洞腔前后,通过扫描电子显微镜(SEM)观察氧化锆钻、不锈钢钻以及钻后的骨表面。对于骨腔愈合模型,拔除Wistar大鼠的上颌第一和第二磨牙。4周后,在左侧用氧化锆钻制备洞腔。作为对照,右侧使用不锈钢钻。术后3天、7天和14天拍摄微型CT图像。制备样本进行组织学染色。

结果

SEM图像显示,即使经过30次钻孔操作后,氧化锆钻仍保持锋利。使用氧化锆钻时骨表面更光滑。微型CT图像显示氧化锆钻洞腔的骨愈合更快且更早。在苏木精-伊红(H-E)染色中,7天时,氧化锆钻造成的缺损空白腔隙面积更小。14天时,氧化锆钻造成的缺损被新形成的骨填充。

结论

氧化锆钻在制备洞腔过程中造成的损伤较小,有利于骨愈合。(197字)

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7461/5396264/8715eb9109ef/CID-19-306-g001.jpg

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