Bokslag Anouk, van Weissenbruch Mirjam, Mol Ben Willem, de Groot Christianne J M
Department of Obstetrics and Gynaecology, VU University Medical Center, Amsterdam, The Netherlands.
Department of Pediatrics, Division of Neonatology, VU University Medical Center, Amsterdam, The Netherlands.
Early Hum Dev. 2016 Nov;102:47-50. doi: 10.1016/j.earlhumdev.2016.09.007. Epub 2016 Sep 20.
Preeclampsia is a common pregnancy specific disease, that presents with hypertension and a variety of organ failures, including malfunction of kidneys, liver and lungs. At present, the only definitive treatment of preeclampsia is end the pregnancy and deliver the neonate and placenta. For women with mild preeclampsia in the preterm phase of pregnancy, expectant management is generally indicated to improve fetal maturity, often requiring maternal medical treatment. Last decades, more evidence is available that the underlying mechanism of preeclampsia, endothelial disease, is not limited to pregnancy but increases cardiovascular risk in later life. In this review, we present the most recent insight in preeclampsia with focus on impact on the fetus, short and long-term outcome of offspring's, and long-term outcome of women with a history of preeclampsia.
子痫前期是一种常见的妊娠特有疾病，表现为高血压和多种器官功能衰竭，包括肾脏、肝脏和肺部功能异常。目前，子痫前期唯一确切的治疗方法是终止妊娠并娩出新生儿及胎盘。对于妊娠早产阶段的轻度子痫前期妇女，通常采用期待治疗以提高胎儿成熟度，这往往需要对母体进行药物治疗。在过去几十年中，有更多证据表明，子痫前期的潜在机制——内皮疾病，不仅限于妊娠，还会增加日后生活中的心血管疾病风险。在本综述中，我们阐述了对子痫前期的最新见解，重点关注其对胎儿的影响、子代的短期和长期结局，以及有子痫前期病史女性的长期结局。
