阳离子阿霉素纳米组装体对膀胱癌的高效膀胱内治疗
Efficient intravesical therapy of bladder cancer with cationic doxorubicin nanoassemblies.
作者信息
Jin Xun, Zhang Peilan, Luo Li, Cheng Hao, Li Yunzu, Du Ting, Zou Bingwen, Gou Maling
机构信息
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, People's Republic of China.
Department of Thoracic Oncology, Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, People's Republic of China.
出版信息
Int J Nanomedicine. 2016 Sep 8;11:4535-4544. doi: 10.2147/IJN.S103994. eCollection 2016.
Nanoparticles have promising applications in drug delivery for cancer therapy. Herein, we prepared cationic 1,2-dioleoyl-3-trimethylammonium propane/methoxypoly (ethyleneglycol) (DPP) nanoparticles to deliver doxorubicin (Dox) for intravesical therapy of bladder cancer. The DPP micelles have a mean dynamic diameter of 18.65 nm and a mean zeta potential of +19.6 mV. The DPP micelles could prolong the residence of Dox in the bladder, enhance the penetration of Dox into the bladder wall, and improve cellular uptake of Dox. The encapsulation by DPP micelles significantly improved the anticancer effect of Dox against orthotopic bladder cancer in vivo. This work described a Dox-loaded DPP nanoparticle with potential applications in intravesical therapy of bladder cancer.
纳米颗粒在癌症治疗的药物递送方面具有广阔的应用前景。在此，我们制备了阳离子型1,2 - 二油酰基 - 3 - 三甲基铵丙烷/甲氧基聚（乙二醇）（DPP）纳米颗粒，用于递送阿霉素（Dox）以进行膀胱癌的膀胱内治疗。DPP胶束的平均动态直径为18.65 nm，平均zeta电位为 +19.6 mV。DPP胶束可以延长Dox在膀胱中的停留时间，增强Dox对膀胱壁的渗透，并改善Dox的细胞摄取。DPP胶束的包封显著提高了Dox对原位膀胱癌的体内抗癌效果。这项工作描述了一种负载Dox的DPP纳米颗粒，在膀胱癌的膀胱内治疗中具有潜在应用。
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