呋喃唑酮和呋喃西林对鸡脑γ-氨基丁酸和谷氨酸浓度的影响。

Effect of furazolidone and nitrofurazone on brain gamma-amino butyric acid and glutamate concentrations in chickens.

Ali B H

Department of Veterinary Medicine, Pharmacology and Toxicology, University of Khartoum, Sudan.

Clin Exp Pharmacol Physiol. 1989 May;16(5):363-6. doi: 10.1111/j.1440-1681.1989.tb01572.x.

Abstract

The concentrations of gamma-amino butyric acid (GABA) and glutamate were measured in the brains of chickens which were treated with furazolidone (FZ) or nitrofurazone (NF) at oral doses of 12.5, 25 or 50 mg/kg for 5 days. 2. At the end of the treatment, the birds lost about 9% of their bodyweight when on the small dose of FZ or NF and about 18% when on the high doses. 3. Both drugs produced dose-dependent increases in the concentrations of GABA and glutamate which were statistically significant at doses of 25 and 50 mg/kg of NF, and 50 mg/kg of FZ.

摘要

给鸡口服12.5、25或50mg/kg的呋喃唑酮（FZ）或呋喃西林（NF），持续5天，然后测量鸡脑中γ-氨基丁酸（GABA）和谷氨酸的浓度。2. 治疗结束时，低剂量FZ或NF组的鸡体重减轻约9%，高剂量组约减轻18%。3. 两种药物均使GABA和谷氨酸浓度呈剂量依赖性增加，NF剂量为25和50mg/kg以及FZ剂量为50mg/kg时，这种增加具有统计学意义。