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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Department of Veterinary Medicine, Pharmacology and Toxicology, University of Khartoum, Sudan.

Clin Exp Pharmacol Physiol. 1989 May;16(5):363-6. doi: 10.1111/j.1440-1681.1989.tb01572.x.

The concentrations of gamma-amino butyric acid (GABA) and glutamate were measured in the brains of chickens which were treated with furazolidone (FZ) or nitrofurazone (NF) at oral doses of 12.5, 25 or 50 mg/kg for 5 days. 2. At the end of the treatment, the birds lost about 9% of their bodyweight when on the small dose of FZ or NF and about 18% when on the high doses. 3. Both drugs produced dose-dependent increases in the concentrations of GABA and glutamate which were statistically significant at doses of 25 and 50 mg/kg of NF, and 50 mg/kg of FZ.

给鸡口服12.5、25或50mg/kg的呋喃唑酮（FZ）或呋喃西林（NF），持续5天，然后测量鸡脑中γ-氨基丁酸（GABA）和谷氨酸的浓度。2. 治疗结束时，低剂量FZ或NF组的鸡体重减轻约9%，高剂量组约减轻18%。3. 两种药物均使GABA和谷氨酸浓度呈剂量依赖性增加，NF剂量为25和50mg/kg以及FZ剂量为50mg/kg时，这种增加具有统计学意义。

Department of Veterinary Medicine, Pharmacology and Toxicology, University of Khartoum, Sudan.

Clin Exp Pharmacol Physiol. 1989 May;16(5):363-6. doi: 10.1111/j.1440-1681.1989.tb01572.x.

The concentrations of gamma-amino butyric acid (GABA) and glutamate were measured in the brains of chickens which were treated with furazolidone (FZ) or nitrofurazone (NF) at oral doses of 12.5, 25 or 50 mg/kg for 5 days. 2. At the end of the treatment, the birds lost about 9% of their bodyweight when on the small dose of FZ or NF and about 18% when on the high doses. 3. Both drugs produced dose-dependent increases in the concentrations of GABA and glutamate which were statistically significant at doses of 25 and 50 mg/kg of NF, and 50 mg/kg of FZ.

给鸡口服12.5、25或50mg/kg的呋喃唑酮（FZ）或呋喃西林（NF），持续5天，然后测量鸡脑中γ-氨基丁酸（GABA）和谷氨酸的浓度。2. 治疗结束时，低剂量FZ或NF组的鸡体重减轻约9%，高剂量组约减轻18%。3. 两种药物均使GABA和谷氨酸浓度呈剂量依赖性增加，NF剂量为25和50mg/kg以及FZ剂量为50mg/kg时，这种增加具有统计学意义。