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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Department of Veterinary Medicine, Pharmacology and Toxicology, University of Khartoum, Sudan.

Clin Exp Pharmacol Physiol. 1988 Dec;15(12):959-63. doi: 10.1111/j.1440-1681.1988.tb01042.x.

The concentrations of gamma-amino butyric acid (GABA) and glutamate were measured in the brains of chickens which were treated with furazolidone (FZ) or nitrofurazone (NF) at oral doses of 12.5, 25 or 50 mg/kg for 5 days. 2. At the end of the treatment, birds on the small dose of FZ or NF lost about 9% of their bodyweight, and those on the high doses lost about 18%. 3. Both drugs produced dose-dependent increases in the concentrations of GAA and glutamate which were statistically significant at doses of 25 and 50 mg/kg of NF and 50 mg/kg of FZ.

给鸡口服12.5、25或50毫克/千克的呋喃唑酮（FZ）或呋喃西林（NF），持续5天，然后测量鸡脑中γ-氨基丁酸（GABA）和谷氨酸的浓度。2. 治疗结束时，服用小剂量FZ或NF的鸡体重减轻了约9%，而服用高剂量的鸡体重减轻了约18%。3. 两种药物均使GAA和谷氨酸浓度呈剂量依赖性增加，在NF剂量为25和50毫克/千克以及FZ剂量为50毫克/千克时，这种增加具有统计学意义。

Department of Veterinary Medicine, Pharmacology and Toxicology, University of Khartoum, Sudan.

Clin Exp Pharmacol Physiol. 1988 Dec;15(12):959-63. doi: 10.1111/j.1440-1681.1988.tb01042.x.

The concentrations of gamma-amino butyric acid (GABA) and glutamate were measured in the brains of chickens which were treated with furazolidone (FZ) or nitrofurazone (NF) at oral doses of 12.5, 25 or 50 mg/kg for 5 days. 2. At the end of the treatment, birds on the small dose of FZ or NF lost about 9% of their bodyweight, and those on the high doses lost about 18%. 3. Both drugs produced dose-dependent increases in the concentrations of GAA and glutamate which were statistically significant at doses of 25 and 50 mg/kg of NF and 50 mg/kg of FZ.

给鸡口服12.5、25或50毫克/千克的呋喃唑酮（FZ）或呋喃西林（NF），持续5天，然后测量鸡脑中γ-氨基丁酸（GABA）和谷氨酸的浓度。2. 治疗结束时，服用小剂量FZ或NF的鸡体重减轻了约9%，而服用高剂量的鸡体重减轻了约18%。3. 两种药物均使GAA和谷氨酸浓度呈剂量依赖性增加，在NF剂量为25和50毫克/千克以及FZ剂量为50毫克/千克时，这种增加具有统计学意义。