An Electrophilic Reagent for the Direct Introduction of the SCF PO(OEt) Group to Molecules.

An unprecedented electrophilic difluoromethylthiolating reagent (MesNHSCF PO(OEt) ) was designed. Under mild and metal-free conditions, this new reagent reacted with various nucleophiles, thus offering an efficient and operationally simple tool for the construction of C-SCF PO(OR) , N-SCF PO(OR) , and S-SCF PO(OR) bonds. Finally, thanks to this new methodology, the synthesis of the non-stereoidal anti-inflammatory diflumidone was achieved.