Normandie Univ, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000, Rouen, France.
Angew Chem Int Ed Engl. 2016 Oct 17;55(43):13490-13494. doi: 10.1002/anie.201607231. Epub 2016 Sep 26.
An unprecedented electrophilic difluoromethylthiolating reagent (MesNHSCF PO(OEt) ) was designed. Under mild and metal-free conditions, this new reagent reacted with various nucleophiles, thus offering an efficient and operationally simple tool for the construction of C-SCF PO(OR) , N-SCF PO(OR) , and S-SCF PO(OR) bonds. Finally, thanks to this new methodology, the synthesis of the non-stereoidal anti-inflammatory diflumidone was achieved.
设计了一种前所未有的亲电二氟甲基硫代试剂（MesNHSCFPO(OEt) ）。在温和无金属条件下，该新试剂与各种亲核试剂反应，从而为构建 C-SCFPO(OR)、N-SCFPO(OR)和 S-SCFPO(OR)键提供了一种高效且操作简单的工具。最后，得益于这种新方法，实现了非甾体抗炎药双氯芬酸的合成。
