纺锤体组装检查点：不止是追踪纺锤体。
The spindle assembly checkpoint: More than just keeping track of the spindle.
作者信息
Lawrence Katherine S, Engebrecht JoAnne
机构信息
Department of Molecular and Cellular Biology, University of California Davis, One Shields Ave, Davis, California 95616, USA.
出版信息
Trends Cell Mol Biol. 2015;10:141-150.
Abstract
Genome stability is essential for cell proliferation and survival. Consequently, genome integrity is monitored by two major checkpoints, the DNA damage response (DDR) and the spindle assembly checkpoint (SAC). The DDR monitors DNA lesions in G1, S, and G2 stages of the cell cycle and the SAC ensures proper chromosome segregation in M phase. There have been extensive studies characterizing the roles of these checkpoints in response to the processes for which they are named; however, emerging evidence suggests significant crosstalk between the checkpoints. Here we review recent findings demonstrating overlapping roles for the SAC and DDR in metaphase, and in response to DNA damage throughout the cell cycle.
摘要
基因组稳定性对于细胞增殖和存活至关重要。因此，基因组完整性由两个主要检查点监测，即DNA损伤反应（DDR）和纺锤体组装检查点（SAC）。DDR监测细胞周期G1、S和G2期的DNA损伤，而SAC确保M期染色体的正确分离。已经有大量研究描述了这些检查点在对其命名的过程作出反应中的作用；然而，新出现的证据表明检查点之间存在显著的相互作用。在这里，我们综述了最近的研究结果，这些结果表明SAC和DDR在中期以及整个细胞周期对DNA损伤的反应中具有重叠作用。
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