载类固醇的止血纳米颗粒可对抗爆炸伤后的肺损伤。
Steroid-Loaded Hemostatic Nanoparticles Combat Lung Injury after Blast Trauma.
作者信息
Hubbard William B, Lashof-Sullivan Margaret M, Lavik Erin B, VandeVord Pamela J
机构信息
School of Biomedical Engineering and Sciences, Virginia Tech University, Blacksburg, VA.
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH.
出版信息
ACS Macro Lett. 2015 Apr 21;4(4):387-391. doi: 10.1021/acsmacrolett.5b00061. Epub 2015 Mar 23.
Abstract
In response to the lack of therapeutics for internal bleeding following a traumatic event, we synthesized hemostatic dexamethasone nanoparticles (hDNP) to help alleviate internal hemorrhaging. hDNP consist of a block copolymer, poly(lactic-co-glycolic acid)-poly(l-lysine)-poly(ethylene glycol) conjugated to a peptide, glycine-arginine-glycine-aspartic acid-serine (GRGDS). These particles were evaluated as treatment for primary blast lung injury in a rodent model. Animals were randomly placed into test and control groups, exposed to blast and given immediate injection. Recovery was assessed using physiological parameters and immunohistochemistry. We found that dexamethasone-loaded hemostatic nanoparticles alleviate physiological deprivation caused by blast injury and reduce lung injury damage.
摘要
针对创伤后内出血治疗方法的缺乏，我们合成了止血地塞米松纳米颗粒（hDNP）以帮助减轻内出血。hDNP由一种嵌段共聚物聚（乳酸-乙醇酸）-聚（L-赖氨酸）-聚（乙二醇）与一种肽甘氨酸-精氨酸-甘氨酸-天冬氨酸-丝氨酸（GRGDS）共轭组成。这些颗粒在啮齿动物模型中作为原发性爆震性肺损伤的治疗方法进行了评估。动物被随机分为试验组和对照组，暴露于爆炸并立即注射。使用生理参数和免疫组织化学评估恢复情况。我们发现载有地塞米松的止血纳米颗粒减轻了爆炸伤引起的生理剥夺并减少了肺损伤。
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