Thadepalli H, Bansal M B, Marshall R, Prabhala R H
Department of Medicine, Charles R. Drew University of Medicine and Science/UCLA, School of Medicine.
Chemotherapy. 1989;35(3):153-9. doi: 10.1159/000238663.
The effects of alterations in pH, size of inoculum, addition of human serum, and repeated exposure to sub-minimum inhibitory concentration of ciprofloxacin against anaerobic bacteria were assessed. Increase in the size of the inoculum and human serum had no effect on the minimum inhibitory concentration, whereas decrease in pH and exposure to sub-MIC decreased the activity of ciprofloxacin against Bacteroides fragilis. We tested for synergism of ciprofloxacin with cefoxitin, clindamycin and metronidazole against B. fragilis.
评估了pH值改变、接种量大小、添加人血清以及反复暴露于低于环丙沙星对厌氧菌最低抑菌浓度的情况下所产生的影响。接种量的增加和人血清对最低抑菌浓度没有影响，而pH值降低和暴露于低于最低抑菌浓度的环境会降低环丙沙星对脆弱拟杆菌的活性。我们测试了环丙沙星与头孢西丁、克林霉素和甲硝唑对脆弱拟杆菌的协同作用。
