Bansal M B, Thadepalli H
Antimicrob Agents Chemother. 1987 Apr;31(4):619-21. doi: 10.1128/AAC.31.4.619.
We determined the MICs of difloxacin (A-56619) and A-56620 against anaerobic bacteria and assessed the effects of alterations in pH, size of inoculum, addition of human serum, and repeated exposure to subinhibitory levels of antibiotics. We tested for synergism of these drugs with cefoxitin against Bacteroides spp. We found that difloxacin and A-56620 were as active as ciprofloxacin, inhibiting about 90% of B. fragilis (4 micrograms/ml) and other Bacteroides spp. (8 micrograms/ml), A-56620 being more active than difloxacin against several isolates. Increased inoculum size and changes in pH did not alter their MICs much, but human serum and exposure to sub-MICs of antibiotic effected increases in their MICs against Bacteroides spp. Cefoxitin was not synergistic with either difloxacin or A-56620 against B. fragilis.
我们测定了双氟沙星（A-56619）和A-56620对厌氧菌的最低抑菌浓度（MIC），并评估了pH值变化、接种量大小、添加人血清以及反复接触亚抑菌浓度抗生素的影响。我们测试了这些药物与头孢西丁对拟杆菌属的协同作用。我们发现双氟沙星和A-56620与环丙沙星活性相当，抑制约90%的脆弱拟杆菌（4微克/毫升）和其他拟杆菌属（8微克/毫升），A-56620对几种分离株的活性比双氟沙星更强。接种量增加和pH值变化对其MIC影响不大，但人血清和接触抗生素亚抑菌浓度会导致其对拟杆菌属的MIC增加。头孢西丁与双氟沙星或A-56620对脆弱拟杆菌均无协同作用。
