• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Antimicrobial spectrum of Win 49375.Win 49375的抗菌谱
Antimicrob Agents Chemother. 1984 Jul;26(1):104-7. doi: 10.1128/AAC.26.1.104.
2
Ciprofloxacin, a quinolone carboxylic acid compound active against aerobic and anaerobic bacteria.环丙沙星，一种对需氧菌和厌氧菌均有活性的喹诺酮羧酸化合物。
Antimicrob Agents Chemother. 1984 Mar;25(3):319-26. doi: 10.1128/AAC.25.3.319.
3
Is ciprofloxacin active against clinically important anaerobes?
J Antimicrob Chemother. 1986 May;17(5):605-13. doi: 10.1093/jac/17.5.605.
4
Effect of inoculum, pH, and medium on the activity of ciprofloxacin against anaerobic bacteria.接种量、pH值和培养基对环丙沙星抗厌氧菌活性的影响。
Antimicrob Agents Chemother. 1984 Mar;25(3):342-3. doi: 10.1128/AAC.25.3.342.
5
A-61827 (A-60969), a new fluoronaphthyridine with activity against both aerobic and anaerobic bacteria.A-61827（A-60969），一种新型氟萘啶，对需氧菌和厌氧菌均有活性。
Antimicrob Agents Chemother. 1988 Jan;32(1):27-32. doi: 10.1128/AAC.32.1.27.
6
Antibacterial activity of amifloxacin (WIN 49, 375), a new quinolone agent.
Diagn Microbiol Infect Dis. 1985 Nov;3(6):469-78. doi: 10.1016/s0732-8893(85)80003-1.
7
The comparative in-vitro activity of eight newer quinolones and nalidixic acid.八种新型喹诺酮类药物与萘啶酸的体外活性比较
J Antimicrob Chemother. 1986 Nov;18 Suppl D:1-20. doi: 10.1093/jac/18.supplement_d.1.
8
Comparative in vitro antimicrobial activity of a novel quinolone, garenoxacin, against aerobic and anaerobic microbial isolates recovered from general, vascular, cardiothoracic and otolaryngologic surgical patients.新型喹诺酮类药物加替沙星对从普通外科、血管外科、心胸外科和耳鼻喉科手术患者中分离出的需氧和厌氧微生物菌株的体外抗菌活性比较
J Antimicrob Chemother. 2005 Nov;56(5):872-8. doi: 10.1093/jac/dki348. Epub 2005 Sep 26.
9
In vitro susceptibilities of 393 recent clinical isolates to WIN 49375, cefotaxime, tobramycin, and piperacillin.393株近期临床分离株对WIN 49375、头孢噻肟、妥布霉素和哌拉西林的体外药敏试验结果。
Antimicrob Agents Chemother. 1984 Mar;25(3):377-9. doi: 10.1128/AAC.25.3.377.
10
In vitro and in vivo antibacterial activities of the fluoroquinolone WIN 49375 (amifloxacin).氟喹诺酮类药物WIN 49375（阿米氟沙星）的体外和体内抗菌活性
Antimicrob Agents Chemother. 1985 Jan;27(1):4-10. doi: 10.1128/AAC.27.1.4.

引用本文的文献

1
In vitro and in vivo antibacterial activities of the fluoroquinolone WIN 49375 (amifloxacin).氟喹诺酮类药物WIN 49375（阿米氟沙星）的体外和体内抗菌活性
Antimicrob Agents Chemother. 1985 Jan;27(1):4-10. doi: 10.1128/AAC.27.1.4.
2
Randomized prospective study comparing moxalactam and cefoxitin with or without tobramycin for the treatment of serious surgical infections.比较羟羧氧酰胺菌素和头孢西丁联合或不联合妥布霉素治疗严重外科感染的随机前瞻性研究。
Antimicrob Agents Chemother. 1986 Feb;29(2):244-9. doi: 10.1128/AAC.29.2.244.
3
Comparison of in vitro activity of quinolone antibiotics and vancomycin against gentamicin- and methicillin-resistant Staphylococcus aureus by time-kill kinetic studies.通过时间杀菌动力学研究比较喹诺酮类抗生素和万古霉素对庆大霉素耐药及耐甲氧西林金黄色葡萄球菌的体外活性。
Antimicrob Agents Chemother. 1986 Dec;30(6):823-7. doi: 10.1128/AAC.30.6.823.
4
Therapeutic evaluation of difloxacin (A-56619) and A-56620 for experimentally induced Bacteroides fragilis-associated intra-abdominal abscess.地氟沙星（A-56619）和A-56620对实验性诱导的脆弱拟杆菌相关性腹腔内脓肿的治疗评估。
Antimicrob Agents Chemother. 1986 Oct;30(4):574-6. doi: 10.1128/AAC.30.4.574.
5
Activity of E-3846, a new fluoroquinolone, in vitro and in experimental cystitis and pyelonephritis in rats.新型氟喹诺酮类药物E-3846在体外以及大鼠实验性膀胱炎和肾盂肾炎中的活性
Antimicrob Agents Chemother. 1988 May;32(5):636-41. doi: 10.1128/AAC.32.5.636.
6
The fluoroquinolones: structures, mechanisms of action and resistance, and spectra of activity in vitro.氟喹诺酮类药物：结构、作用机制与耐药性以及体外活性谱
Antimicrob Agents Chemother. 1985 Oct;28(4):581-6. doi: 10.1128/AAC.28.4.581.
7
In vitro comparison of A-56619, A-56620, amifloxacin, ciprofloxacin, enoxacin, norfloxacin, and ofloxacin against methicillin-resistant Staphylococcus aureus.A-56619、A-56620、阿米氟沙星、环丙沙星、依诺沙星、诺氟沙星和氧氟沙星对耐甲氧西林金黄色葡萄球菌的体外比较
Antimicrob Agents Chemother. 1986 Feb;29(2):325-6. doi: 10.1128/AAC.29.2.325.
8
Fluoroquinolone antimicrobial agents.氟喹诺酮类抗菌剂。
Clin Microbiol Rev. 1989 Oct;2(4):378-424. doi: 10.1128/CMR.2.4.378.
9
In vitro activity of amifloxacin against outer membrane mutants of the family Enterobacteriaceae and frequency of spontaneous resistance.阿米氟沙星对肠杆菌科外膜突变体的体外活性及自发耐药频率
Antimicrob Agents Chemother. 1989 Nov;33(11):1837-40. doi: 10.1128/AAC.33.11.1837.

本文引用的文献

1
beta-Lactamase activity in human pus.人脓液中的β-内酰胺酶活性
J Infect Dis. 1980 Oct;142(4):594-601. doi: 10.1093/infdis/142.4.594.
2
In vitro activity of azthreonam, a monobactam antibiotic.单环β-内酰胺类抗生素氨曲南的体外活性
Antimicrob Agents Chemother. 1982 Nov;22(5):832-8. doi: 10.1128/AAC.22.5.832.
3
In vitro activity of norfloxacin in urine compared to that of cinnoxacin, nalidixic acid and pipemidic acid.与西诺沙星、萘啶酸和吡哌酸相比，诺氟沙星在尿液中的体外活性。
Eur J Clin Microbiol. 1983 Jun;2(3):272-4. doi: 10.1007/BF02029533.
4
Susceptibility of anaerobes to cefoxitin and other cephalosporins.厌氧菌对头孢西丁及其他头孢菌素的敏感性。
Antimicrob Agents Chemother. 1975 Feb;7(2):128-32. doi: 10.1128/AAC.7.2.128.

Win 49375的抗菌谱

Antimicrobial spectrum of Win 49375.

作者信息

Jacobus N V, Tally F P, Barza M

出版信息

Antimicrob Agents Chemother. 1984 Jul;26(1):104-7. doi: 10.1128/AAC.26.1.104.

DOI:10.1128/AAC.26.1.104
PMID:6476813
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC179928/
Abstract

Win 49375 had excellent activity against members of the family Enterobacteriaceae and staphylococcal species. Its activity against Pseudomonas aeruginosa was equal to that of gentamicin. Win 49375 had moderate activity against clostridia but little against Bacteroides fragilis. The drug showed a marked inoculum effect at 10(8) CFU/ml and a slight decrease in potency at pH 5.

摘要

Win 49375对肠杆菌科细菌和葡萄球菌属具有优异的活性。其对铜绿假单胞菌的活性与庆大霉素相当。Win 49375对梭菌属有中等活性，但对脆弱拟杆菌活性较弱。该药物在10⁸CFU/ml时显示出明显的接种物效应，在pH 5时效力略有下降。