IncX3-X4 杂合质粒在大肠杆菌中共同转移 bla 和 mcr-1 基因。
Co-transfer of bla and mcr-1 by an IncX3-X4 hybrid plasmid in Escherichia coli.
作者信息
Sun Jian, Yang Run-Shi, Zhang Qijing, Feng Youjun, Fang Liang-Xing, Xia Jing, Li Liang, Lv Xiao-Yue, Duan Jia-Hong, Liao Xiao-Ping, Liu Ya-Hong
机构信息
National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou 510642, China.
College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
出版信息
Nat Microbiol. 2016 Sep 26;1:16176. doi: 10.1038/nmicrobiol.2016.176.
Carbapenem and colistin are the last-resort antibiotics used for treating multidrug-resistant Gram-negative pathogens. Here, we report, for the first time, co-transfer of resistance to both classes of antibiotics by a mobile IncX3-X4 hybrid plasmid in an Escherichia coli isolate. Spread of such a plasmid is of great concern for clinical therapy, and heightened efforts are needed to control its dissemination.
碳青霉烯类和黏菌素是用于治疗多重耐药革兰氏阴性病原体的最后手段抗生素。在此，我们首次报道了一种可移动的IncX3-X4杂种质粒在一株大肠杆菌分离株中共同传递对这两类抗生素的耐药性。这种质粒的传播对临床治疗极为令人担忧，需要加大力度控制其传播。
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