伸长因子通过调节肌动球蛋白动力学来控制皮层中间神经元的迁移。
Elongator controls cortical interneuron migration by regulating actomyosin dynamics.
作者信息
Tielens Sylvia, Huysseune Sandra, Godin Juliette D, Chariot Alain, Malgrange Brigitte, Nguyen Laurent
机构信息
GIGA-Neurosciences, 4000 Liège, Belgium.
Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R), 4000 Liège, Belgium.
出版信息
Cell Res. 2016 Oct;26(10):1131-1148. doi: 10.1038/cr.2016.112. Epub 2016 Sep 27.
Abstract
The migration of cortical interneurons is a fundamental process for the establishment of cortical connectivity and its impairment underlies several neurological disorders. During development, these neurons are born in the ganglionic eminences and they migrate tangentially to populate the cortical layers. This process relies on various morphological changes that are driven by dynamic cytoskeleton remodelings. By coupling time lapse imaging with molecular analyses, we show that the Elongator complex controls cortical interneuron migration in mouse embryos by regulating nucleokinesis and branching dynamics. At the molecular level, Elongator fine-tunes actomyosin forces by regulating the distribution and turnover of actin microfilaments during cell migration. Thus, we demonstrate that Elongator cell-autonomously promotes cortical interneuron migration by controlling actin cytoskeletal dynamics.
摘要
皮质中间神经元的迁移是建立皮质连接的一个基本过程，其受损是多种神经疾病的基础。在发育过程中，这些神经元在神经节隆起处产生，并沿切线方向迁移以填充皮质层。这个过程依赖于由动态细胞骨架重塑驱动的各种形态变化。通过将延时成像与分子分析相结合，我们发现Elongator复合物通过调节核运动和分支动力学来控制小鼠胚胎中皮质中间神经元的迁移。在分子水平上，Elongator通过在细胞迁移过程中调节肌动蛋白微丝的分布和周转来微调肌动球蛋白力。因此，我们证明Elongator通过控制肌动蛋白细胞骨架动力学在细胞自主水平上促进皮质中间神经元的迁移。
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